PMID- 10631952
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20190915
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 172
DP  - 1999 Dec
TI  - The impact of the non-classical MHC proteins HLA-DM and HLA-DO on loading of MHC 
      class II molecules.
PG  - 267-78
AB  - Peptide binding to classical major histocompatibility complex (MHC) class II
      molecules is known to be determined by the properties of the class II peptide
      binding groove but recently it turned out to be co-controlled by the activity of 
      the non-classical MHC molecules HLA-DM and HLA-DO: HLA-DM functions as a mediator
      of peptide exchange. In addition, HLA-DM is a chaperone for MHC class II
      molecules in endosomal and lysosomal loading compartments because it stabilizes
      the empty MHC class II peptide binding groove and keeps it receptive for peptide 
      loading until appropriate peptide ligands are captured. Since HLA-DM favors the
      generation of high-stability peptide-MHC class II complexes by releasing
      low-stability peptide ligands, DM activity affects the peptide repertoire
      presented on the cell surface of antigen-presenting cells. HLA-DO is expressed
      mainly in B cells and binds tightly to HLA-DM thereby modulating its activity.
      Together, HLA-DM and HLA-DO are critical factors in shaping the MHC class
      II-associated self or foreign peptide repertoire of antigen presenting cells and,
      hence, govern initiation or prevention of an immune response.
FAU - Kropshofer, H
AU  - Kropshofer H
AD  - Department of Molecular Immunology, German Cancer Research Center, Heidelberg,
      Germany.
FAU - Hammerling, G J
AU  - Hammerling GJ
FAU - Vogt, A B
AU  - Vogt AB
LA  - eng
PT  - Journal Article
PT  - Review
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
RN  - 0 (H-2O antigen)
RN  - 0 (H2-M antigens)
RN  - 0 (HLA-D Antigens)
RN  - 0 (HLA-DM antigens)
RN  - 0 (HLA-DO antigens)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Molecular Chaperones)
RN  - 0 (Peptides)
SB  - IM
MH  - Antigen Presentation
MH  - B-Lymphocytes/immunology
MH  - Genes, MHC Class II
MH  - HLA-D Antigens/*metabolism
MH  - Histocompatibility Antigens Class II/*metabolism
MH  - Humans
MH  - Models, Biological
MH  - Molecular Chaperones/immunology/metabolism
MH  - Peptides/immunology/metabolism
MH  - Protein Binding
MH  - T-Lymphocytes/immunology
RF  - 89
EDAT- 2000/01/13 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/13 09:00
PHST- 2000/01/13 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/13 09:00 [entrez]
AID - 10.1111/j.1600-065x.1999.tb01371.x [doi]
PST - ppublish
SO  - Immunol Rev. 1999 Dec;172:267-78. doi: 10.1111/j.1600-065x.1999.tb01371.x.