PMID- 10631168
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20081121
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 127
IP  - 3
DP  - 2000 Feb
TI  - Hippocampus development and generation of dentate gyrus granule cells is
      regulated by LEF1.
PG  - 469-82
AB  - Lef1 and other genes of the LEF1/TCF family of transcription factors are nuclear 
      mediators of Wnt signaling. Here we examine the expression pattern and functional
      importance of Lef1 in the developing forebrain of the mouse. Lef1 is expressed in
      the developing hippocampus, and LEF1-deficient embryos lack dentate gyrus granule
      cells but contain glial cells and interneurons in the region of the dentate
      gyrus. In mouse embryos homozygous for a Lef1-lacZ fusion gene, which encodes a
      protein that is not only deficient in DNA binding but also interferes with
      (beta)-catenin-mediated transcriptional activation by other LEF1/TCF proteins,
      the entire hippocampus including the CA fields is missing. Thus, LEF1 regulates
      the generation of dentate gyrus granule cells, and together with other LEF1/TCF
      proteins, the development of the hippocampus.
FAU - Galceran, J
AU  - Galceran J
AD  - Howard Hughes Medical Institute, Department of Microbiology, University of
      California, San Francisco, CA 94143, USA.
FAU - Miyashita-Lin, E M
AU  - Miyashita-Lin EM
FAU - Devaney, E
AU  - Devaney E
FAU - Rubenstein, J L
AU  - Rubenstein JL
FAU - Grosschedl, R
AU  - Grosschedl R
LA  - eng
GR  - K02 MH01046-01/MH/NIMH NIH HHS/United States
GR  - NS34661-01A1/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Lef1 protein, mouse)
RN  - 0 (Lymphoid Enhancer-Binding Factor 1)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 3.2.1.23 (beta-Galactosidase)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - DNA-Binding Proteins/deficiency/*genetics/physiology
MH  - Dentate Gyrus/cytology/*embryology
MH  - Embryonic and Fetal Development
MH  - *Gene Expression Regulation, Developmental
MH  - Hippocampus/cytology/*embryology
MH  - Homozygote
MH  - Interneurons/cytology/physiology
MH  - Lymphoid Enhancer-Binding Factor 1
MH  - Mice
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - Neuroglia/cytology/physiology
MH  - Prosencephalon/cytology/*embryology
MH  - Recombinant Proteins/biosynthesis
MH  - Transcription Factors/deficiency/*genetics/physiology
MH  - Transcriptional Activation
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - beta-Galactosidase/genetics
EDAT- 2000/01/13 09:00
MHDA- 2000/03/11 09:00
CRDT- 2000/01/13 09:00
PHST- 2000/01/13 09:00 [pubmed]
PHST- 2000/03/11 09:00 [medline]
PHST- 2000/01/13 09:00 [entrez]
PST - ppublish
SO  - Development. 2000 Feb;127(3):469-82.