PMID- 10631096
OWN - NLM
STAT- MEDLINE
DCOM- 20000223
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 267
IP  - 2
DP  - 2000 Jan 19
TI  - Alternative splicing and expression of the mouse estrogen receptor-related
      receptor gamma.
PG  - 532-5
AB  - Estrogen receptor-related receptors (ERRs) are orphan members of the nuclear
      receptor superfamily, closely related to the estrogen receptor. With a PCR-based 
      cloning strategy we have identified two cDNA isoforms from a neonatal mouse whole
      brain cDNA library encoding ERRgamma. We show that alternative splicing gives
      rise to different 5'-ends. The predicted peptide sequence of ERRgamma2 differs
      from ERRgamma1 by additional 23 N-terminal residues. The presence of identical
      isoforms in human suggests a pivotal function of ERRgamma in mammalia. Northern
      blot analysis reveals that ERRgamma is expressed as early as day 11 of embryonic 
      development (E11). Whole mount in situ hybridization analysis shows major
      expression of ERRgamma in the central nervous system at E12.5. In the adult mouse
      a 5.7 kb transcript is detected in heart, brain, kidney, and skeletal muscle.
      Therefore, ERRgamma may be involved in the differentiation, as well as the
      maintenance of the differentiated properties in the brain.
CI  - Copyright 2000 Academic Press.
FAU - Susens, U
AU  - Susens U
AD  - Zentrum fur Molekulare Neurobiologie, Universitat Hamburg, Martinistrasse 52,
      Hamburg, D-20246, Germany.
FAU - Hermans-Borgmeyer, I
AU  - Hermans-Borgmeyer I
FAU - Borgmeyer, U
AU  - Borgmeyer U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (DNA Primers)
RN  - 0 (DNA, Complementary)
RN  - 0 (ESRRG protein, human)
RN  - 0 (Esrrg protein, mouse)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Estrogen)
SB  - IM
MH  - *Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Central Nervous System/embryology/metabolism
MH  - Cloning, Molecular
MH  - DNA Primers/genetics
MH  - DNA, Complementary/genetics
MH  - Embryonic and Fetal Development/genetics
MH  - Female
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - In Situ Hybridization
MH  - Mice
MH  - Molecular Sequence Data
MH  - Pregnancy
MH  - Protein Isoforms/genetics
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptors, Cytoplasmic and Nuclear/*genetics
MH  - *Receptors, Estrogen
MH  - Tissue Distribution
EDAT- 2000/01/13 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/13 09:00
PHST- 2000/01/13 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/13 09:00 [entrez]
AID - 10.1006/bbrc.1999.1976 [doi]
AID - S0006-291X(99)91976-9 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Jan 19;267(2):532-5. doi:
      10.1006/bbrc.1999.1976.