PMID- 10629060
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 20
IP  - 3
DP  - 2000 Feb
TI  - Interaction of a mitogen-activated protein kinase signaling module with the
      neuronal protein JIP3.
PG  - 1030-43
AB  - The c-Jun NH(2)-terminal kinase (JNK) group of mitogen-activated protein kinases 
      (MAPKs) is activated in response to the treatment of cells with inflammatory
      cytokines and by exposure to environmental stress. JNK activation is mediated by 
      a protein kinase cascade composed of a MAPK kinase and a MAPK kinase kinase. Here
      we describe the molecular cloning of a putative molecular scaffold protein, JIP3,
      that binds the protein kinase components of a JNK signaling module and
      facilitates JNK activation in cultured cells. JIP3 is expressed in the brain and 
      at lower levels in the heart and other tissues. Immunofluorescence analysis
      demonstrated that JIP3 was present in the cytoplasm and accumulated in the growth
      cones of developing neurites. JIP3 is a member of a novel class of putative MAPK 
      scaffold proteins that may regulate signal transduction by the JNK pathway.
FAU - Kelkar, N
AU  - Kelkar N
AD  - Howard Hughes Medical Institute, Program in Molecular Medicine, Department of
      Biochemistry, University of Massachusetts Medical School, Worcester,
      Massachusetts 01605, USA.
FAU - Gupta, S
AU  - Gupta S
FAU - Dickens, M
AU  - Dickens M
FAU - Davis, R J
AU  - Davis RJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Mapk8ip3 protein, mouse)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
RN  - EC 2.7.11.25 (MAP Kinase Kinase Kinases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Aging
MH  - Amino Acid Sequence
MH  - Animals
MH  - Brain/*metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Embryonic and Fetal Development
MH  - Enzyme Activation
MH  - Female
MH  - *Gene Expression Regulation, Developmental
MH  - Gene Library
MH  - JNK Mitogen-Activated Protein Kinases
MH  - MAP Kinase Kinase Kinases/metabolism
MH  - Male
MH  - Mice
MH  - Mitogen-Activated Protein Kinases/chemistry/*metabolism
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/chemistry/genetics/*metabolism
MH  - Neurons/metabolism
MH  - Protein Isoforms/chemistry/genetics/metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
PMC - PMC85220
EDAT- 2000/01/11 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/11 09:00
PHST- 2000/01/11 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/11 09:00 [entrez]
AID - 10.1128/mcb.20.3.1030-1043.2000 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2000 Feb;20(3):1030-43. doi: 10.1128/mcb.20.3.1030-1043.2000.