PMID- 10629050
OWN - NLM
STAT- MEDLINE
DCOM- 20000214
LR  - 20190508
IS  - 0270-7306 (Print)
IS  - 0270-7306 (Linking)
VI  - 20
IP  - 3
DP  - 2000 Feb
TI  - Bid induces the oligomerization and insertion of Bax into the outer mitochondrial
      membrane.
PG  - 929-35
AB  - In many types of apoptosis, the proapoptotic protein Bax undergoes a change in
      conformation at the level of the mitochondria. This event always precedes the
      release of mitochondrial cytochrome c, which, in the cytosol, activates caspases 
      through binding to Apaf-1. The mechanisms by which Bax triggers cytochrome c
      release are unknown. Here we show that following binding to the BH3-domain-only
      proapoptotic protein Bid, Bax oligomerizes and then integrates in the outer
      mitochondrial membrane, where it triggers cytochrome c release. Bax mitochondrial
      membrane insertion triggered by Bid may represent a key step in pathways leading 
      to apoptosis.
FAU - Eskes, R
AU  - Eskes R
AD  - Serono Pharmaceutical Research Institute, Ares Serono International S.A., CH-1228
      Plan-les Ouates, Geneva, Switzerland.
FAU - Desagher, S
AU  - Desagher S
FAU - Antonsson, B
AU  - Antonsson B
FAU - Martinou, J C
AU  - Martinou JC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mol Cell Biol
JT  - Molecular and cellular biology
JID - 8109087
RN  - 0 (BAX protein, human)
RN  - 0 (BH3 Interacting Domain Death Agonist Protein)
RN  - 0 (BID protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytochrome c Group)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-2)
RN  - 0 (bcl-2-Associated X Protein)
RN  - H88EPA0A3N (Staurosporine)
RN  - KOO5CM684H (Digitonin)
SB  - IM
MH  - Apoptosis
MH  - BH3 Interacting Domain Death Agonist Protein
MH  - Carrier Proteins/*metabolism
MH  - Cytochrome c Group/metabolism
MH  - Digitonin/pharmacology
MH  - Genes, bcl-2
MH  - HeLa Cells
MH  - Humans
MH  - Intracellular Membranes/drug effects/*metabolism
MH  - Mitochondria/drug effects/*metabolism
MH  - Models, Biological
MH  - Protein Structure, Quaternary
MH  - Proto-Oncogene Proteins/chemistry/*metabolism
MH  - Proto-Oncogene Proteins c-bcl-2/genetics/metabolism
MH  - Signal Transduction
MH  - Staurosporine/pharmacology
MH  - bcl-2-Associated X Protein
PMC - PMC85210
EDAT- 2000/01/11 09:00
MHDA- 2000/02/19 09:00
CRDT- 2000/01/11 09:00
PHST- 2000/01/11 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 2000/01/11 09:00 [entrez]
AID - 10.1128/mcb.20.3.929-935.2000 [doi]
PST - ppublish
SO  - Mol Cell Biol. 2000 Feb;20(3):929-35. doi: 10.1128/mcb.20.3.929-935.2000.