PMID- 10627596
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20191023
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 20
IP  - 1
DP  - 2000 Jan 1
TI  - Ninjurin2, a novel homophilic adhesion molecule, is expressed in mature sensory
      and enteric neurons and promotes neurite outgrowth.
PG  - 187-95
AB  - A large number of cell adhesion molecules mediate cell-to-cell and
      cell-to-extracellular matrix interaction during development, differentiation and 
      regeneration of the peripheral nervous system. Here, we report the identification
      of a novel cell surface adhesion molecule, ninjurin2 (for nerve injury induced
      protein 2). Ninjurin2 is a homolog of a homophilic cellular adhesion molecule,
      ninjurin1, that was previously isolated as a gene induced in Schwann cells after 
      nerve injury. Ninjurin1 and 2 share conserved hydrophobic regions for their
      transmembrane domains; however, they do not contain comparable adhesion motifs
      nor do they interact with each other. In the peripheral nervous system, ninjurin2
      is expressed constitutively in mature sensory and enteric neurons but not in
      glial cells or in autonomic ganglia. Ninjurin2 is upregulated in Schwann cells
      surrounding the distal segment of injured nerve with a time course similar to
      that of ninjurin1, neural CAM, and L1. Ninjurin2 promotes neurite outgrowth from 
      primary cultured dorsal root ganglion neurons, presumably via homophilic cellular
      interactions. Ninjurin2 is also highly expressed in hematopoietic and lymphatic
      tissues. Finally, the ninjurin2 gene is located on human chromosome 12p13 in
      which several disorders of unknown etiology have been mapped, including
      inflammatory bowel disease and acrocallosal syndrome.
FAU - Araki, T
AU  - Araki T
AD  - Division of Laboratory Medicine, Department of Pathology and Medicine, Washington
      University School of Medicine, St. Louis, Missouri 63110, USA.
FAU - Milbrandt, J
AU  - Milbrandt J
LA  - eng
GR  - 5P01CA49712/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for
      Neuroscience
JID - 8102140
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (NINJ2 protein, human)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Ninj2 protein, mouse)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - CHO Cells
MH  - Cell Adhesion/physiology
MH  - Cell Adhesion Molecules, Neuronal/analysis/*genetics
MH  - Cell Division/physiology
MH  - Cell Membrane/chemistry
MH  - Chromosome Mapping
MH  - Cricetinae
MH  - Enteric Nervous System/chemistry/cytology
MH  - Ganglia, Spinal/chemistry/cytology
MH  - Gene Expression/physiology
MH  - Humans
MH  - Jurkat Cells
MH  - Mice
MH  - Mitosis
MH  - Molecular Sequence Data
MH  - Nerve Growth Factors/analysis/*genetics
MH  - Neurites/*chemistry/physiology
MH  - Neuroglia/chemistry/physiology
MH  - Neurons, Afferent/*chemistry/physiology/ultrastructure
MH  - RNA, Messenger/analysis
MH  - Schwann Cells/chemistry/physiology
MH  - Sciatic Nerve/cytology/injuries
MH  - Sequence Homology, Amino Acid
PMC - PMC6774113
EDAT- 2000/01/11 00:00
MHDA- 2000/01/11 00:01
CRDT- 2000/01/11 00:00
PHST- 2000/01/11 00:00 [pubmed]
PHST- 2000/01/11 00:01 [medline]
PHST- 2000/01/11 00:00 [entrez]
PST - ppublish
SO  - J Neurosci. 2000 Jan 1;20(1):187-95.