PMID- 10626844
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 277
IP  - 3
DP  - 1999 Dec 31
TI  - Expression of the mRNA for two isoforms of neural plakophilin-related arm-repeat 
      protein/delta-catenin in rodent neurons and glial cells.
PG  - 185-8
AB  - Neural plakophilin-related arm-repeat protein (NPRAP) is a mammalian brain
      protein of the armadillo family. Here, in an attempt to elucidate its function,
      we determined the mouse brain regions and cell types expressing the mRNAs for two
      NPRAP isoforms (the longer and the shorter isoforms), and examined the regulation
      of expression of the NPRAP mRNAs during the differentiation of P19 cells into
      neurons. Reverse transcription-polymerase chain reaction (RT-PCR) analysis
      revealed that both variants were expressed in various mouse brain regions, but
      the mRNA for the short isoform was predominant in most regions. Primary cultures 
      of both neurons and glial cells exhibited high expression levels of both the
      mRNAs, indicating that NPRAP mRNA expression is not neuron-specific. The
      expression of the two NPRAP mRNA variants was dramatically induced even prior to 
      the terminal neuronal and glial differentiation of P19 cells after retinoic acid 
      treatment. These data suggest that the two NPRAP isoforms function not only in
      neurons and glial cells in the brain, but also play a role in the differentiation
      of precursor cells into neurons and glial cells.
FAU - Kawamura, Y
AU  - Kawamura Y
AD  - Department of Dementia Research, National Institute for Longevity Sciences, Obu, 
      Aichi, Japan.
FAU - Fan, Q W
AU  - Fan QW
FAU - Hayashi, H
AU  - Hayashi H
FAU - Michikawa, M
AU  - Michikawa M
FAU - Yanagisawa, K
AU  - Yanagisawa K
FAU - Komano, H
AU  - Komano H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Armadillo Domain Proteins)
RN  - 0 (Catenins)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Ctnnd2 protein, rat)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (RNA, Messenger)
RN  - 0 (delta catenin)
RN  - 5688UTC01R (Tretinoin)
SB  - IM
MH  - Animals
MH  - Armadillo Domain Proteins
MH  - Catenins
MH  - Cell Adhesion Molecules
MH  - Cells, Cultured
MH  - Cytoskeletal Proteins
MH  - Mice
MH  - Nerve Tissue Proteins/*genetics
MH  - Neuroglia/drug effects/*metabolism
MH  - Neurons/drug effects/*metabolism
MH  - Phosphoproteins
MH  - Protein Isoforms/genetics
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Tretinoin/pharmacology
EDAT- 2000/01/08 00:00
MHDA- 2000/01/08 00:01
CRDT- 2000/01/08 00:00
PHST- 2000/01/08 00:00 [pubmed]
PHST- 2000/01/08 00:01 [medline]
PHST- 2000/01/08 00:00 [entrez]
AID - S0304394099008757 [pii]
AID - 10.1016/s0304-3940(99)00875-7 [doi]
PST - ppublish
SO  - Neurosci Lett. 1999 Dec 31;277(3):185-8. doi: 10.1016/s0304-3940(99)00875-7.