PMID- 10625660
OWN - NLM
STAT- MEDLINE
DCOM- 20000218
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 275
IP  - 2
DP  - 2000 Jan 14
TI  - Four new members expand the interleukin-1 superfamily.
PG  - 1169-75
AB  - We report here the cloning and characterization of four new members of the
      interleukin-1 (IL-1) family (FIL1delta, FIL1epsilon, FIL1zeta, and FIL1eta, with 
      FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant
      sequence similarity to IL-1alpha, IL-1beta, IL-1ra, and IL-18, and in addition
      maintain a conserved exon-intron arrangement that is shared with the previously
      known members of the family. Protein structure modeling also suggests that the
      FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster
      with the IL-1s on the long arm of human chromosome 2.
FAU - Smith, D E
AU  - Smith DE
AD  - Immunex Corp., Seattle, Washington 98101, USA.
FAU - Renshaw, B R
AU  - Renshaw BR
FAU - Ketchem, R R
AU  - Ketchem RR
FAU - Kubin, M
AU  - Kubin M
FAU - Garka, K E
AU  - Garka KE
FAU - Sims, J E
AU  - Sims JE
LA  - eng
SI  - GENBANK/AF201830
SI  - GENBANK/AF201831
SI  - GENBANK/AF201832
SI  - GENBANK/AF201833
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Interleukin-1)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Interleukin-1)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Cell Line
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 2
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Exons
MH  - Female
MH  - Genomic Library
MH  - Humans
MH  - Interleukin-1/chemistry/*genetics/metabolism
MH  - Introns
MH  - Male
MH  - Mice
MH  - Models, Molecular
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Open Reading Frames
MH  - Protein Conformation
MH  - Protein Isoforms/chemistry/genetics/metabolism
MH  - Protein Structure, Secondary
MH  - Receptors, Interleukin-1/metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Tumor Cells, Cultured
EDAT- 2000/01/08 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/08 09:00
PHST- 2000/01/08 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/08 09:00 [entrez]
AID - 10.1074/jbc.275.2.1169 [doi]
AID - S0021-9258(18)31232-8 [pii]
PST - ppublish
SO  - J Biol Chem. 2000 Jan 14;275(2):1169-75. doi: 10.1074/jbc.275.2.1169.