PMID- 10625658
OWN - NLM
STAT- MEDLINE
DCOM- 20000218
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 275
IP  - 2
DP  - 2000 Jan 14
TI  - Both PCE-1/RX and OTX/CRX interactions are necessary for photoreceptor-specific
      gene expression.
PG  - 1152-60
AB  - RX, a homeodomain-containing protein essential for proper eye development
      (Mathers, P. H. Grinberg, A., Mahon, K. A., and Jamrich, M. (1997) Nature 387,
      603-607), binds to the photoreceptor conserved element-1 (PCE-1/Ret 1) in the
      photoreceptor cell-specific arrestin promoter and stimulates gene expression. RX 
      is found in many retinal cell types including photoreceptor cells. Another
      homeodomain-containing protein, CRX, which binds to the OTX element to stimulate 
      promoter activity, is found exclusively in photoreceptor cells (Chen, S., Wang,
      Q. L., Nie, Z., Sun, H., Lennon, G., Copeland, N. G., Gillbert, D. J. Jenkins, N.
      A., and Zack, D. J. (1997) Neuron 19, 1017-1030; Furukawa, T., Morrow, E. M., and
      Cepko, C. L. (1997) Cell 91, 531-541). Binding assay and cell culture studies
      indicate that both PCE-1 and OTX elements and at least two different regulatory
      factors RX and CRX are necessary for high level, photoreceptor cell-restricted
      gene expression. Thus, photoreceptor specificity can be achieved by multiple
      promoter elements interacting with a combination of both photoreceptor-specific
      regulatory factors and factors present in closely related cell lineages.
FAU - Kimura, A
AU  - Kimura A
AD  - Center for Ophthalmic Research, Brigham & Women's Hospital, Department of
      Ophthalmology, Harvard Medical School, Boston, Massachusetts 02115, USA.
FAU - Singh, D
AU  - Singh D
FAU - Wawrousek, E F
AU  - Wawrousek EF
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Nakamura, M
AU  - Nakamura M
FAU - Shinohara, T
AU  - Shinohara T
LA  - eng
SI  - GENBANK/AF115392
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (Arrestin)
RN  - 0 (Eye Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Oligonucleotide Probes)
RN  - 0 (RAX protein, human)
RN  - 0 (Rax protein, mouse)
RN  - 0 (Recombinant Fusion Proteins)
RN  - 0 (Rx protein, vertebrate)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (cone rod homeobox protein)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Arrestin/*genetics
MH  - Base Sequence
MH  - Brain/metabolism
MH  - Cattle
MH  - Chickens
MH  - Conserved Sequence
MH  - *Eye Proteins
MH  - *Gene Expression Regulation
MH  - Gene Library
MH  - Homeodomain Proteins/chemistry/genetics/*metabolism
MH  - Humans
MH  - Introns
MH  - Iris/metabolism
MH  - Lens, Crystalline/metabolism
MH  - Liver/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes
MH  - Photoreceptor Cells, Vertebrate/*metabolism
MH  - Promoter Regions, Genetic
MH  - Recombinant Fusion Proteins/biosynthesis
MH  - Retina/*metabolism
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Trans-Activators/chemistry/genetics/*metabolism
MH  - *Transcription Factors
MH  - Transcriptional Activation
EDAT- 2000/01/08 09:00
MHDA- 2000/02/26 09:00
CRDT- 2000/01/08 09:00
PHST- 2000/01/08 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 2000/01/08 09:00 [entrez]
AID - 10.1074/jbc.275.2.1152 [doi]
AID - S0021-9258(18)31230-4 [pii]
PST - ppublish
SO  - J Biol Chem. 2000 Jan 14;275(2):1152-60. doi: 10.1074/jbc.275.2.1152.