PMID- 10625539
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20141120
IS  - 0012-1606 (Print)
IS  - 0012-1606 (Linking)
VI  - 217
IP  - 1
DP  - 2000 Jan 1
TI  - The mammalian Odz gene family: homologs of a Drosophila pair-rule gene with
      expression implying distinct yet overlapping developmental roles.
PG  - 107-20
AB  - The Drosophila pair-rule gene odz (Tenm) has many patterning roles throughout
      development. We have identified four mammalian homologs of this gene, including
      one previously described as a mouse ER stress response gene, Doc4 (Wang et al.,
      1998). The Odz genes encode large polypeptides displaying the hallmarks of
      Drosophila Odz: a putative signal peptide; eight EGF-like repeats; and a putative
      transmembrane domain followed by a 1800-amino-acid stretch without homology to
      any proteins outside of this family. The mouse genes Odz3 and Doc4/Odz4 exhibit
      partially overlapping, but clearly distinct, embryonic expression patterns. The
      major embryonic sites of expression are in the nervous system, including the
      tectum, optic recess, optic stalk, and developing eye. Additional sites of
      expression include trachea and mesodermally derived tissues, such as mesentery,
      and forming limb and bone. Expression of the Odz2 gene is restricted to the
      nervous system. The expression patterns suggest that each of the genes has its
      own distinct developmental role. Comparisons of Drosophila and vertebrate Odz
      expression patterns suggest evolutionarily conserved functions.
CI  - Copyright 2000 Academic Press.
FAU - Ben-Zur, T
AU  - Ben-Zur T
AD  - Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, 52900, Israel.
FAU - Feige, E
AU  - Feige E
FAU - Motro, B
AU  - Motro B
FAU - Wides, R
AU  - Wides R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Dev Biol
JT  - Developmental biology
JID - 0372762
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Tenascin)
RN  - 0 (teneurin-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Cloning, Molecular
MH  - DNA, Complementary
MH  - *Gene Expression Regulation, Developmental
MH  - Human Genome Project
MH  - Humans
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Nerve Tissue Proteins
MH  - Sequence Homology, Amino Acid
MH  - *Tenascin
EDAT- 2000/01/08 00:00
MHDA- 2000/01/08 00:01
CRDT- 2000/01/08 00:00
PHST- 2000/01/08 00:00 [pubmed]
PHST- 2000/01/08 00:01 [medline]
PHST- 2000/01/08 00:00 [entrez]
AID - 10.1006/dbio.1999.9532 [doi]
AID - S0012-1606(99)99532-5 [pii]
PST - ppublish
SO  - Dev Biol. 2000 Jan 1;217(1):107-20. doi: 10.1006/dbio.1999.9532.