PMID- 10623617
OWN - NLM
STAT- MEDLINE
DCOM- 20000208
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 267
IP  - 1
DP  - 2000 Jan 7
TI  - Sequence, organization, and expression of the human FEM1B gene.
PG  - 317-20
AB  - The FEM-1 protein of Caenorhabditis elegans functions within the nematode
      sex-determination pathway. Two mouse homologs, encoded by the Fem1a and Fem1b
      genes, have been reported. We report here the characterization of a novel human
      gene, designated FEM1B, that is highly homologous to the mouse Fem1b gene. FEM1B 
      encodes a protein, designated FEM1beta, that shows >99% amino acid identity to
      the corresponding mouse Fem1b protein, including 100% amino acid identity in the 
      N-terminal ANK repeat domain. FEM1beta represents the first characterized human
      member of the FEM-1 protein family. The human and mouse genes show conservation
      of coding sequence and its intron/exon organization, flanking untranslated and
      genomic sequences, and expression pattern in adult tissues. These findings
      suggest that there may be evolutionary conservation of regulation and function
      between the mouse and human FEM1B genes.
CI  - Copyright 2000 Academic Press.
FAU - Ventura-Holman, T
AU  - Ventura-Holman T
AD  - Department of Medicine, Division of Hematology, University of Mississippi Medical
      Center, Jackson, Mississippi, 39216, USA.
FAU - Maher, J F
AU  - Maher JF
LA  - eng
SI  - GENBANK/AF204883
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Caenorhabditis elegans Proteins)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (FEM-1 protein, C elegans)
RN  - 0 (FEM1B protein, human)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.3.2.23 (Fem1b protein, mouse)
RN  - EC 2.3.2.23 (Ubiquitin-Protein Ligase Complexes)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Caenorhabditis elegans/genetics
MH  - *Caenorhabditis elegans Proteins
MH  - *Carrier Proteins
MH  - Cell Cycle Proteins/biosynthesis/chemistry/*genetics
MH  - Cloning, Molecular
MH  - Conserved Sequence
MH  - Exons
MH  - Humans
MH  - Introns
MH  - Mice
MH  - Molecular Sequence Data
MH  - Recombinant Proteins/biosynthesis/chemistry
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Ubiquitin-Protein Ligase Complexes
EDAT- 2000/01/07 00:00
MHDA- 2000/01/07 00:01
CRDT- 2000/01/07 00:00
PHST- 2000/01/07 00:00 [pubmed]
PHST- 2000/01/07 00:01 [medline]
PHST- 2000/01/07 00:00 [entrez]
AID - 10.1006/bbrc.1999.1942 [doi]
AID - S0006-291X(99)91942-3 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Jan 7;267(1):317-20. doi:
      10.1006/bbrc.1999.1942.