PMID- 10623590
OWN - NLM
STAT- MEDLINE
DCOM- 20000208
LR  - 20191210
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 267
IP  - 1
DP  - 2000 Jan 7
TI  - Interaction of the PDZ domain of human PICK1 with class I ADP-ribosylation
      factors.
PG  - 149-55
AB  - We have cloned the cDNA encoding human PICK1 (protein interacting with C kinase
      1), a PDZ domain-containing protein of 415 amino acids, and also identified the
      Drosophila homologue by search of the databank. Northern blot analysis shows a
      single mRNA of about 2.0 kb ubiquitously expressed in human tissues. Although
      PICK1 proteins harbor a region homologous to arfaptin1 and arfaptin2, two
      proteins that bind to the ARF (ADP-ribosylation factor), this region of PICK1
      does not interact with ARFs in the yeast two-hybrid system. On the other hand,
      the PDZ domain of PICK1 is capable of interacting with constitutively active,
      GTP-bound forms of ARF1 and ARF3, but neither with those of ARF5/6 nor with the
      GDP-bound ARFs. The PICK1-ARF interaction is abrogated by introduction of
      mutations in the PDZ domain or by deletion of the extreme C-terminus of ARF1.
      Thus, PICK1 specifically interacts with ARF1/3 in the GTP-bound state, suggesting
      that PICK1 participates in ARF1/3-mediated cellular processes.
CI  - Copyright 2000 Academic Press.
FAU - Takeya, R
AU  - Takeya R
AD  - Department of Molecular Biology, Kyushu University Graduate School of Medical
      Science, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
FAU - Takeshige, K
AU  - Takeshige K
FAU - Sumimoto, H
AU  - Sumimoto H
LA  - eng
SI  - GENBANK/AB026491
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (ARFIP1 protein, human)
RN  - 0 (ARFIP2 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (PICk1 protein, human)
RN  - 0 (Prkcabp protein, mouse)
RN  - 0 (RNA, Messenger)
RN  - EC 3.6.5.2 (ADP-Ribosylation Factors)
RN  - EC 3.6.5.2 (Arf5 protein, mouse)
SB  - IM
MH  - ADP-Ribosylation Factors/*metabolism
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Caenorhabditis elegans/genetics
MH  - Carrier Proteins/*chemistry/genetics/*metabolism
MH  - Cell Cycle Proteins
MH  - Drosophila melanogaster/genetics
MH  - Humans
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/*chemistry/genetics/*metabolism
MH  - RNA, Messenger/genetics
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Transcription, Genetic
EDAT- 2000/01/07 00:00
MHDA- 2000/01/07 00:01
CRDT- 2000/01/07 00:00
PHST- 2000/01/07 00:00 [pubmed]
PHST- 2000/01/07 00:01 [medline]
PHST- 2000/01/07 00:00 [entrez]
AID - 10.1006/bbrc.1999.1932 [doi]
AID - S0006-291X(99)91932-0 [pii]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2000 Jan 7;267(1):149-55. doi:
      10.1006/bbrc.1999.1932.