PMID- 10622746
OWN - NLM
STAT- MEDLINE
DCOM- 20000202
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 462
IP  - 3
DP  - 1999 Dec 3
TI  - Somatostatin receptor subtype 1 modulates basal inhibition of growth hormone
      release in somatotrophs.
PG  - 464-6
AB  - Somatostatin (SST) inhibits the secretion of many peptide hormones including
      growth hormone (GH). The various functions of SST are mediated through at least
      five different receptor subtypes (SSTR1-5), their precise physiological roles
      have not been solved yet. Here we report on studies concerning the functional
      role of SSTR1 in the modulation of GH release from somatotrophs. Primary cell
      cultures from pituitaries of wild-type SSTR1 mice exposed to the SSTR1 selective 
      somatostatin analog CH-275 show reduction of basal levels of GH secretion whereas
      somatotrophs isolated from SSTR1 null mutant mice did not respond to the
      agonist-mediated effect. This suggests that SSTR1 is involved in modulating basal
      GH levels in primary pituitary cell cultures and, together with SSTR2, may
      control the secretion of GH in the body.
FAU - Kreienkamp, H J
AU  - Kreienkamp HJ
AD  - Institut fur Zellbiochemie und klinische Neurobiologie, Universitat Hamburg,
      Germany.
FAU - Akgun, E
AU  - Akgun E
FAU - Baumeister, H
AU  - Baumeister H
FAU - Meyerhof, W
AU  - Meyerhof W
FAU - Richter, D
AU  - Richter D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (CH 275)
RN  - 0 (Receptors, Somatostatin)
RN  - 51110-01-1 (Somatostatin)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Blotting, Northern
MH  - Blotting, Southern
MH  - Cells, Cultured
MH  - Growth Hormone/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Mutagenesis, Insertional
MH  - Pituitary Gland/drug effects/*metabolism
MH  - Receptors, Somatostatin/genetics/*physiology
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Somatostatin/analogs & derivatives/pharmacology
EDAT- 2000/01/06 00:00
MHDA- 2000/01/06 00:01
CRDT- 2000/01/06 00:00
PHST- 2000/01/06 00:00 [pubmed]
PHST- 2000/01/06 00:01 [medline]
PHST- 2000/01/06 00:00 [entrez]
AID - S0014-5793(99)01582-3 [pii]
AID - 10.1016/s0014-5793(99)01582-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 3;462(3):464-6. doi: 10.1016/s0014-5793(99)01582-3.