PMID- 10622531
OWN - NLM
STAT- MEDLINE
DCOM- 20000106
LR  - 20190513
IS  - 0910-5050 (Print)
IS  - 0910-5050 (Linking)
VI  - 90
IP  - 11
DP  - 1999 Nov
TI  - Increased choline kinase activity in 1,2-dimethylhydrazine-induced rat colon
      cancer.
PG  - 1212-7
AB  - Cancer cells acquire particular characteristics that benefit their proliferation.
      We previously reported that human colon cancers examined had increased choline
      kinase activity and phosphocholine levels. The elevated phosphocholine levels
      were in part due to both activation of choline kinase and increased choline
      kinase alpha protein levels. In this report, we analyzed choline kinase, which
      catalyzes the phosphorylation of choline to produce phosphocholine, in rat
      1,2-dimethylhydrazine (DMH)-induced colon cancer. This study is the first to
      demonstrate increased choline kinase alpha enzymatic activity, protein levels,
      and mRNA levels in DMH-induced colon cancer as well as human colon cancer,
      although phosphocholine was not increased in DMH-induced rat cancer. The increase
      in the mRNA level was partly due to an increase in the transcription of the
      choline kinase alpha gene. The increased choline kinase activity may be a
      specific characteristic acquired by cancer cells that benefits their
      proliferation.
FAU - Nakagami, K
AU  - Nakagami K
AD  - Second Department of Surgery, Gunma University School of Medicine, Maebashi.
FAU - Uchida, T
AU  - Uchida T
FAU - Ohwada, S
AU  - Ohwada S
FAU - Koibuchi, Y
AU  - Koibuchi Y
FAU - Morishita, Y
AU  - Morishita Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn J Cancer Res
JT  - Japanese journal of cancer research : Gann
JID - 8509412
RN  - 0 (Carcinogens)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.1.32 (Choline Kinase)
RN  - IX068S9745 (1,2-Dimethylhydrazine)
SB  - IM
MH  - 1,2-Dimethylhydrazine
MH  - Animals
MH  - Carcinogens
MH  - Choline Kinase/genetics/*metabolism
MH  - Colonic Neoplasms/*chemically induced/*enzymology
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Wistar
PMC - PMC5926018
EDAT- 2000/01/06 00:00
MHDA- 2000/01/06 00:01
CRDT- 2000/01/06 00:00
PHST- 2000/01/06 00:00 [pubmed]
PHST- 2000/01/06 00:01 [medline]
PHST- 2000/01/06 00:00 [entrez]
AID - S091050500087653X [pii]
AID - 10.1111/j.1349-7006.1999.tb00698.x [doi]
PST - ppublish
SO  - Jpn J Cancer Res. 1999 Nov;90(11):1212-7. doi:
      10.1111/j.1349-7006.1999.tb00698.x.