PMID- 10621841
OWN - NLM
STAT- MEDLINE
DCOM- 20000120
LR  - 20191103
IS  - 1368-8375 (Print)
IS  - 1368-8375 (Linking)
VI  - 35
IP  - 3
DP  - 1999 May
TI  - Matrix metalloproteinases and oral cancer.
PG  - 227-33
AB  - For tumours to invade and metastasise, neoplastic cells must be capable of
      degrading the extracellular matrix (ECM), and accessing blood vessels and
      lymphatics. This process is mediated in the pericellular environment and is a
      highly controlled cascade of events utilising the same mechanisms that normal
      cells use for migrating through tissue barriers, for example, in development and 
      wound healing. Proteolytic enzymes from several families, including matrix
      metalloproteinases (MMPs), are involved in ECM remodelling. Increased production 
      of these enzymes has been associated with the invasive and/or metastatic
      phenotype in many tumours. Several MMPs have been shown to play a role in the
      invasion and metastasis of oral carcinoma, and it is increasingly apparent that
      tumour cells, as well as producing endogenous MMP, are capable of utilising MMP
      produced by tumour stromal cells, indicating an active role for stroma in tumour 
      invasion. It is not clear whether a particular invasive system is favoured by
      oral carcinoma, but it is likely that further understanding of the interactions
      between carcinoma and stromal cells will provide an opportunity to refine the
      therapeutic interventions that are currently being tested.
FAU - Thomas, G T
AU  - Thomas GT
AD  - Department of Oral Pathology, Eastman Dental Institute for Oral Healthcare
      Sciences, University of London, UK.
FAU - Lewis, M P
AU  - Lewis MP
FAU - Speight, P M
AU  - Speight PM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Oral Oncol
JT  - Oral oncology
JID - 9709118
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - Carcinoma, Squamous Cell/enzymology/pathology
MH  - Humans
MH  - Matrix Metalloproteinase 3/metabolism
MH  - Matrix Metalloproteinases/*physiology
MH  - Mouth Neoplasms/*enzymology/pathology
MH  - Neoplasm Invasiveness
MH  - Neoplasm Proteins/*physiology
MH  - Peptide Hydrolases/metabolism
MH  - Tissue Inhibitor of Metalloproteinase-1/metabolism
RF  - 52
EDAT- 2000/01/06 00:00
MHDA- 2000/01/06 00:01
CRDT- 2000/01/06 00:00
PHST- 2000/01/06 00:00 [pubmed]
PHST- 2000/01/06 00:01 [medline]
PHST- 2000/01/06 00:00 [entrez]
AID - S1368-8375(99)00004-4 [pii]
AID - 10.1016/s1368-8375(99)00004-4 [doi]
PST - ppublish
SO  - Oral Oncol. 1999 May;35(3):227-33. doi: 10.1016/s1368-8375(99)00004-4.