PMID- 10620491
OWN - NLM
STAT- MEDLINE
DCOM- 20000302
LR  - 20181113
IS  - 0264-6021 (Print)
IS  - 0264-6021 (Linking)
VI  - 345 Pt 2
DP  - 2000 Jan 15
TI  - The uncoupling protein homologues: UCP1, UCP2, UCP3, StUCP and AtUCP.
PG  - 161-79
AB  - Animal and plant uncoupling protein (UCP) homologues form a subfamily of
      mitochondrial carriers that are evolutionarily related and possibly derived from 
      a proton/anion transporter ancestor. The brown adipose tissue (BAT) UCP1 has a
      marked and strongly regulated uncoupling activity, essential to the maintenance
      of body temperature in small mammals. UCP homologues identified in plants are
      induced in a cold environment and may be involved in resistance to chilling. The 
      biochemical activities and biological functions of the recently identified
      mammalian UCP2 and UCP3 are not well known. However, recent data support a role
      for these UCPs in State 4 respiration, respiration uncoupling and proton leaks in
      mitochondria. Moreover, genetic studies suggest that UCP2 and UCP3 play a part in
      energy expenditure in humans. The UCPs may also be involved in adaptation of
      cellular metabolism to an excessive supply of substrates in order to regulate the
      ATP level, the NAD(+)/NADH ratio and various metabolic pathways, and to contain
      superoxide production. A major goal will be the analysis of mice that either lack
      the UCP2 or UCP3 gene or overexpress these genes. Other aims will be to
      investigate the possible roles of UCP2 and UCP3 in response to oxidative stress, 
      lipid peroxidation, inflammatory processes, fever and regulation of temperature
      in certain specific parts of the body.
FAU - Ricquier, D
AU  - Ricquier D
AD  - Centre de Recherche sur l'Endocrinologie Moleculaire et le Developpement
      (CEREMOD), Centre National de la recherche Scientifique (CNRS-Unit 9078), 9 rue
      Jules Hetzel, 92190 Meudon, France. ricquier@infobiogen.fr
FAU - Bouillaud, F
AU  - Bouillaud F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Biochem J
JT  - The Biochemical journal
JID - 2984726R
RN  - 0 (Carrier Proteins)
RN  - 0 (Plant Proteins)
RN  - 0 (Uncoupling Agents)
SB  - IM
MH  - Adipose Tissue, Brown/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/classification/genetics/*metabolism
MH  - Energy Metabolism/*physiology
MH  - Evolution, Molecular
MH  - Hot Temperature
MH  - Humans
MH  - Mice
MH  - Mitochondria/*metabolism
MH  - Molecular Sequence Data
MH  - Oxygen Consumption
MH  - Plant Proteins/classification/genetics/metabolism
MH  - Uncoupling Agents/*metabolism
RF  - 273
PMC - PMC1220743
EDAT- 2000/01/06 09:00
MHDA- 2000/03/04 09:00
CRDT- 2000/01/06 09:00
PHST- 2000/01/06 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 2000/01/06 09:00 [entrez]
PST - ppublish
SO  - Biochem J. 2000 Jan 15;345 Pt 2:161-79.