PMID- 10619433
OWN - NLM
STAT- MEDLINE
DCOM- 20000201
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 7
DP  - 1999 Dec 23
TI  - Dispatched, a novel sterol-sensing domain protein dedicated to the release of
      cholesterol-modified hedgehog from signaling cells.
PG  - 803-15
AB  - Members of the Hedgehog (Hh) family of secreted signaling proteins function as
      potent short-range organizers in animal development. Their range of action is
      limited by a C-terminal cholesterol tether and the upregulation of Patched (Ptc) 
      receptor levels. Here we identify a novel segment-polarity gene in Drosophila,
      dispatched (disp), and demonstrate that its product is required in sending cells 
      for normal Hh function. In the absence of Disp, cholesterol-modified but not
      cholesterol-free Hh is retained in these cells, indicating that Disp functions to
      release cholesterol-anchored Hh. Despite their opposite roles, Disp and Ptc share
      structural homology in the form of a sterol-sensing domain, suggesting that
      release and sequestration of cholesterol-modified Hh may be based on related
      molecular pathways.
FAU - Burke, R
AU  - Burke R
AD  - Institut fur Molekularbiologie, Universitat Zurich, Switzerland.
FAU - Nellen, D
AU  - Nellen D
FAU - Bellotto, M
AU  - Bellotto M
FAU - Hafen, E
AU  - Hafen E
FAU - Senti, K A
AU  - Senti KA
FAU - Dickson, B J
AU  - Dickson BJ
FAU - Basler, K
AU  - Basler K
LA  - eng
SI  - GENBANK/AF200691
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Drosophila Proteins)
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (disp protein, Drosophila)
RN  - 0 (ptc protein, Drosophila)
RN  - 149291-21-4 (hh protein, Drosophila)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cholesterol/*metabolism
MH  - Cloning, Molecular
MH  - Drosophila/embryology/genetics/*metabolism
MH  - *Drosophila Proteins
MH  - Embryo, Nonmammalian
MH  - Hedgehog Proteins
MH  - Immunohistochemistry
MH  - Insect Proteins/genetics/*metabolism
MH  - Larva
MH  - Membrane Proteins/genetics/*metabolism
MH  - Molecular Sequence Data
MH  - Mutation
MH  - Receptors, Cell Surface/genetics/metabolism
MH  - Sequence Alignment
MH  - Signal Transduction/physiology
MH  - Transgenes
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0092-8674(00)81677-3 [pii]
AID - 10.1016/s0092-8674(00)81677-3 [doi]
PST - ppublish
SO  - Cell. 1999 Dec 23;99(7):803-15. doi: 10.1016/s0092-8674(00)81677-3.