PMID- 10618500
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 464
IP  - 3
DP  - 1999 Dec 31
TI  - Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent 
      protein kinase II(1).
PG  - 174-8
AB  - A yeast two-hybrid screen revealed that regulatory subunits (RII) of PKAII bind
      the Yotiao protein. Yotiao interacts with the NR1 subunit of the NMDA receptor. A
      purified C-terminal fragment of Yotiao binds PKAII, via an RII binding site
      constituted by amino acid residues 1452-1469, with a dissociation constant (K(d))
      between 50 and 90 nM in vitro. A stable complex composed of Yotiao, RII and NR1
      was immunoprecipitated from whole rat brain extracts. Immunostaining analysis
      disclosed that Yotiao, RIIbeta and NR1 colocalize in striatal and cerebellar
      neurons. Co-assembly of Yotiao/PKAII complexes with NR1 subunits may promote
      cAMP-dependent modulation of NMDA receptor activity at synapses, thereby
      influencing brain development and synaptic plasticity.
FAU - Feliciello, A
AU  - Feliciello A
AD  - Dipartimento di Biologia e Patologia Molecolare e Cellulare, Centro di
      Endocrinologia ed Oncologia Sperimentale CNR, Facolta di Medicina, Universita
      Federico II, 80131, Naples, Italy. feliciel@unina.it
FAU - Cardone, L
AU  - Cardone L
FAU - Garbi, C
AU  - Garbi C
FAU - Ginsberg, M D
AU  - Ginsberg MD
FAU - Varrone, S
AU  - Varrone S
FAU - Rubin, C S
AU  - Rubin CS
FAU - Avvedimento, E V
AU  - Avvedimento EV
FAU - Gottesman, M E
AU  - Gottesman ME
LA  - eng
SI  - GENBANK/AF133906
GR  - DK50702/DK/NIDDK NIH HHS/United States
GR  - GM 22792/GM/NIGMS NIH HHS/United States
GR  - NS28130/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (A Kinase Anchor Proteins)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Akap9 protein, rat)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (Ligands)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Recombinant Proteins)
RN  - EC 2.7.11.11 (Cyclic AMP-Dependent Protein Kinases)
SB  - IM
MH  - A Kinase Anchor Proteins
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Carrier Proteins/chemistry/*metabolism
MH  - Cyclic AMP-Dependent Protein Kinases/*metabolism
MH  - Cytoskeletal Proteins/chemistry/*metabolism
MH  - Ligands
MH  - Mice
MH  - Molecular Sequence Data
MH  - Protein Binding
MH  - Rats
MH  - Receptors, N-Methyl-D-Aspartate/*metabolism
MH  - Recombinant Proteins/chemistry/metabolism
MH  - Sequence Homology, Amino Acid
MH  - Substrate Specificity
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0014579399015859 [pii]
AID - 10.1016/s0014-5793(99)01585-9 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 31;464(3):174-8. doi: 10.1016/s0014-5793(99)01585-9.