PMID- 10617768
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20171213
IS  - 0031-9333 (Print)
IS  - 0031-9333 (Linking)
VI  - 80
IP  - 1
DP  - 2000 Jan
TI  - Effects of serine/threonine protein phosphatases on ion channels in excitable
      membranes.
PG  - 173-210
AB  - This review deals with the influence of serine/threonine-specific protein
      phosphatases on the function of ion channels in the plasma membrane of excitable 
      tissues. Particular focus is given to developments of the past decade. Most of
      the electrophysiological experiments have been performed with protein phosphatase
      inhibitors. Therefore, a synopsis is required incorporating issues from
      biochemistry, pharmacology, and electrophysiology. First, we summarize the
      structural and biochemical properties of protein phosphatase (types 1, 2A, 2B,
      2C, and 3-7) catalytic subunits and their regulatory subunits. Then the available
      pharmacological tools (protein inhibitors, nonprotein inhibitors, and activators)
      are introduced. The use of these inhibitors is discussed based on their
      biochemical selectivity and a number of methodological caveats. The next section 
      reviews the effects of these tools on various classes of ion channels (i.e.,
      voltage-gated Ca(2+) and Na(+) channels, various K(+) channels, ligand-gated
      channels, and anion channels). We delineate in which cases a direct interaction
      between a protein phosphatase and a given channel has been proven and where a
      more complex regulation is likely involved. Finally, we present ideas for future 
      research and possible pathophysiological implications.
FAU - Herzig, S
AU  - Herzig S
AD  - Institut fur Pharmakologie, Universitat Koln, Koln, Germany.
      stefan.herzig@unikoeln.de
FAU - Neumann, J
AU  - Neumann J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Physiol Rev
JT  - Physiological reviews
JID - 0231714
RN  - 0 (Calcium Channels)
RN  - 0 (Ion Channels)
RN  - 0 (Potassium Channels)
RN  - 0 (Sodium Channels)
RN  - EC 3.1.3.16 (Phosphoprotein Phosphatases)
SB  - IM
MH  - Animals
MH  - Calcium Channels/physiology
MH  - Cell Membrane/*physiology
MH  - Humans
MH  - Ion Channels/*physiology
MH  - Phosphoprotein Phosphatases/chemistry/classification/*metabolism
MH  - Potassium Channels/physiology
MH  - Sodium Channels/physiology
RF  - 471
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1152/physrev.2000.80.1.173 [doi]
PST - ppublish
SO  - Physiol Rev. 2000 Jan;80(1):173-210. doi: 10.1152/physrev.2000.80.1.173.