PMID- 10617605
OWN - NLM
STAT- MEDLINE
DCOM- 20000131
LR  - 20210209
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 275
IP  - 1
DP  - 2000 Jan 7
TI  - Ca(2+)-dependent gene expression mediated by MEF2 transcription factors.
PG  - 197-209
AB  - Ca(2+) induction of a subset of cellular and viral immediate-early activation
      genes in lymphocytes has been previously mapped to response elements recognized
      by the MEF2 family of transcription factors. Here, we demonstrate that Ca(2+)
      activation of MEF2 response elements in T lymphocytes is mediated in synergy by
      two Ca(2+)/calmodulin-dependent enzymes, the phosphatase calcineurin, and the
      kinase type IV/Gr (CaMKIV/Gr), which promote transcription by the MEF2 family
      members MEF2A and MEF2D. Calcineurin up-regulates the activity of both factors by
      an NFAT-dependent mechanism, while CaMKIV/Gr selectively and independently
      activates MEF2D. These results identify MEF2 proteins as effectors of a pathway
      of gene induction in T lymphocytes which integrates diverse Ca(2+) activation
      signals and may be broadly operative in several tissues.
FAU - Blaeser, F
AU  - Blaeser F
AD  - Department of Pediatrics, Center for Immunology, Washington University School of 
      Medicine, St. Louis, Missouri 63110, USA.
FAU - Ho, N
AU  - Ho N
FAU - Prywes, R
AU  - Prywes R
FAU - Chatila, T A
AU  - Chatila TA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MADS Domain Proteins)
RN  - 0 (MEF2 Transcription Factors)
RN  - 0 (MEF2A protein, human)
RN  - 0 (MEF2D protein, human)
RN  - 0 (Mef2a protein, mouse)
RN  - 0 (Mef2d protein, mouse)
RN  - 0 (Myogenic Regulatory Factors)
RN  - 0 (NFATC Transcription Factors)
RN  - 0 (NR4A1 protein, human)
RN  - 0 (Nr4a1 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Subfamily 4, Group A, Member 1)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Recombinant Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.7.11.17 (CAMK4 protein, human)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinase Type 4)
RN  - EC 2.7.11.17 (Calcium-Calmodulin-Dependent Protein Kinases)
RN  - EC 2.7.11.17 (Camk4 protein, mouse)
RN  - EC 3.1.3.16 (Calcineurin)
SB  - IM
MH  - Animals
MH  - Base Sequence
MH  - Calcineurin/metabolism
MH  - *Calcium Signaling
MH  - Calcium-Calmodulin-Dependent Protein Kinase Type 4
MH  - Calcium-Calmodulin-Dependent Protein Kinases/metabolism
MH  - DNA-Binding Proteins/*genetics/*metabolism
MH  - *Gene Expression Regulation
MH  - Humans
MH  - MADS Domain Proteins
MH  - MEF2 Transcription Factors
MH  - Mice
MH  - Molecular Sequence Data
MH  - Myogenic Regulatory Factors
MH  - NFATC Transcription Factors
MH  - *Nuclear Proteins
MH  - Nuclear Receptor Subfamily 4, Group A, Member 1
MH  - Protein Binding
MH  - Receptors, Cytoplasmic and Nuclear
MH  - Receptors, Steroid
MH  - Recombinant Proteins/metabolism
MH  - Response Elements
MH  - T-Lymphocytes/*metabolism
MH  - Transcription Factors/*genetics/*metabolism
MH  - Transcriptional Activation
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - 10.1074/jbc.275.1.197 [doi]
AID - S0021-9258(19)52852-6 [pii]
PST - ppublish
SO  - J Biol Chem. 2000 Jan 7;275(1):197-209. doi: 10.1074/jbc.275.1.197.