PMID- 10617319
OWN - NLM
STAT- MEDLINE
DCOM- 20000207
LR  - 20190915
IS  - 0168-0102 (Print)
IS  - 0168-0102 (Linking)
VI  - 35
IP  - 4
DP  - 1999 Dec 30
TI  - Molecular cloning of a cDNA encoding mouse A15, a member of the transmembrane 4
      superfamily, and its preferential expression in brain neurons.
PG  - 281-90
AB  - A15, a member of the transmembrane 4 superfamily (TM4SF), was isolated by
      differential screening of the cDNAs that are preferentially expressed on immature
      T cells. As a first step in the study of the biological function of the A15
      molecule, we isolated cDNAs encoding the entire coding region of mouse A15.
      Nucleotide sequence analysis of the cDNAs revealed that mouse A15 shares 97%
      amino acid sequence identity with its human counterpart. The mouse A15 protein
      product has not yet been characterized, but is predicted to be 244 amino acids
      with four hydrophobic domains. Northern blot analysis of the RNA samples from
      various mouse tissues disclosed that the A15 transcripts are expressed most
      strongly in the brains, and are detectable in the colon, muscle, heart, kidney,
      and spleen. In situ hybridization of the mouse brain with ribo-probe established 
      that the A15 transcripts are expressed primarily in neurons of the frontal
      cortex, olfactory bulb, dentate gyrus, caudoputamen, and CA3 region of the
      hypothalamus as well as in Purkinje cells in the cerebellar cortex, which
      strongly suggests that A15 may have a special function in the fundamental
      neuronal functioning of the higher nervous system.
FAU - Hosokawa, Y
AU  - Hosokawa Y
AD  - Laboratory of Chemotherapy, Aichi Cancer Center Research Institute, ,Nagoya,
      Japan.
FAU - Ueyama, E
AU  - Ueyama E
FAU - Morikawa, Y
AU  - Morikawa Y
FAU - Maeda, Y
AU  - Maeda Y
FAU - Seto, M
AU  - Seto M
FAU - Senba, E
AU  - Senba E
LA  - eng
SI  - GENBANK/AF052492
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Ireland
TA  - Neurosci Res
JT  - Neuroscience research
JID - 8500749
RN  - 0 (DNA, Complementary)
RN  - 0 (Membrane Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Tm4sf2 protein, mouse)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain Chemistry/genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/*genetics
MH  - Male
MH  - Membrane Proteins/*genetics
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Neurons/chemistry
MH  - RNA, Messenger/analysis
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0168010299000930 [pii]
AID - 10.1016/s0168-0102(99)00093-0 [doi]
PST - ppublish
SO  - Neurosci Res. 1999 Dec 30;35(4):281-90. doi: 10.1016/s0168-0102(99)00093-0.