PMID- 10616523
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 116
IP  - 1
DP  - 2000 Jan 1
TI  - The role of p53 in megakaryocyte differentiation and the megakaryocytic leukemias 
      of Down syndrome.
PG  - 1-5
AB  - Sequence analysis of the p53 tumor suppressor gene was performed on diagnostic 
      blood and bone marrow samples from nine children with Down syndrome and acute 
      megakaryoblastic leukemia. p53 sequence alterations were not observed in any of 
      seven cases of transient leukemia; however, samples from two of three patients 
      with acute megakaryoblastic leukemia harbored sequence alterations. The 
      acquisition of both mutations (Gly245Val and Arg72Pro) in the transformation from 
      transient leukemia to overt acute megakaryoblastic leukemia suggests a functional 
      role of mutant p53 in the evolution of this disease.
FAU - Malkin, D
AU  - Malkin D
AD  - Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
FAU - Brown, E J
AU  - Brown EJ
FAU - Zipursky, A
AU  - Zipursky A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 0 (Tumor Suppressor Protein p53)
RN  - 94ZLA3W45F (Arginine)
RN  - 9DLQ4CIU6V (Proline)
RN  - HG18B9YRS7 (Valine)
RN  - TE7660XO1C (Glycine)
SB  - IM
MH  - Amino Acid Sequence
MH  - Arginine
MH  - Base Sequence
MH  - *Cell Differentiation
MH  - Child
MH  - Child, Preschool
MH  - Down Syndrome/genetics/*pathology
MH  - Female
MH  - Genes, p53
MH  - Glycine
MH  - Humans
MH  - Leukemia, Megakaryoblastic, Acute/genetics/*pathology
MH  - Male
MH  - Megakaryocytes/*pathology
MH  - Mutation
MH  - Proline
MH  - Sequence Analysis, DNA
MH  - Tumor Suppressor Protein p53/*physiology
MH  - Valine
EDAT- 2000/01/05 00:00
MHDA- 2000/01/05 00:01
CRDT- 2000/01/05 00:00
PHST- 2000/01/05 00:00 [pubmed]
PHST- 2000/01/05 00:01 [medline]
PHST- 2000/01/05 00:00 [entrez]
AID - S0165-4608(99)00072-2 [pii]
AID - 10.1016/s0165-4608(99)00072-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 2000 Jan 1;116(1):1-5. doi: 
      10.1016/s0165-4608(99)00072-2.