PMID- 10615049
OWN - NLM
STAT- MEDLINE
DCOM- 20000120
LR  - 20190619
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 287
IP  - 5450
DP  - 2000 Jan 7
TI  - A mammalian H+ channel generated through alternative splicing of the NADPH
      oxidase homolog NOH-1.
PG  - 138-42
AB  - Voltage-gated proton (H+) channels are found in many human and animal tissues and
      play an important role in cellular defense against acidic stress. However, a
      molecular identification of these unique ion conductances has so far not been
      achieved. A 191-amino acid protein is described that, upon heterologous
      expression, has properties indistinguishable from those of native H+ channels.
      This protein is generated through alternative splicing of messenger RNA derived
      from the gene NOH-1 (NADPH oxidase homolog 1, where NADPH is the reduced form of 
      nicotinamide adenine dinucleotide phosphate).
FAU - Banfi, B
AU  - Banfi B
AD  - Biology of Aging Laboratory, Department of Geriatrics, Geneva University
      Hospitals, Geneva Medical School, CH-1211 Geneva 4, Switzerland.
FAU - Maturana, A
AU  - Maturana A
FAU - Jaconi, S
AU  - Jaconi S
FAU - Arnaudeau, S
AU  - Arnaudeau S
FAU - Laforge, T
AU  - Laforge T
FAU - Sinha, B
AU  - Sinha B
FAU - Ligeti, E
AU  - Ligeti E
FAU - Demaurex, N
AU  - Demaurex N
FAU - Krause, K H
AU  - Krause KH
LA  - eng
SI  - GENBANK/AF166326
SI  - GENBANK/AF166327
SI  - GENBANK/AF166328
SI  - GENBANK/AI821410
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Ion Channels)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Protons)
RN  - 7YNJ3PO35Z (Hydrogen)
RN  - EC 1.6.3.- (CYBB protein, human)
RN  - EC 1.6.3.- (NADPH Oxidase 1)
RN  - EC 1.6.3.- (NADPH Oxidase 2)
RN  - EC 1.6.3.- (NADPH Oxidases)
RN  - EC 1.6.3.- (NOX1 protein, human)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
EIN - Science. 2005 Jan 7;307(5706):44
MH  - *Alternative Splicing
MH  - Amino Acid Sequence
MH  - Cell Line
MH  - Cytosol/metabolism
MH  - Electric Conductivity
MH  - Electron Transport
MH  - Expressed Sequence Tags
MH  - Humans
MH  - Hydrogen/*metabolism
MH  - Hydrogen-Ion Concentration
MH  - Ion Channel Gating
MH  - Ion Channels/chemistry/*genetics/metabolism
MH  - Membrane Glycoproteins/chemistry/*genetics
MH  - Molecular Sequence Data
MH  - NADPH Oxidase 1
MH  - NADPH Oxidase 2
MH  - NADPH Oxidases/chemistry/*genetics
MH  - Patch-Clamp Techniques
MH  - Protons
MH  - Transfection
MH  - Tumor Cells, Cultured
MH  - Zinc/pharmacology
EDAT- 1999/12/30 00:00
MHDA- 1999/12/30 00:01
CRDT- 1999/12/30 00:00
PHST- 1999/12/30 00:00 [pubmed]
PHST- 1999/12/30 00:01 [medline]
PHST- 1999/12/30 00:00 [entrez]
AID - 8151 [pii]
AID - 10.1126/science.287.5450.138 [doi]
PST - ppublish
SO  - Science. 2000 Jan 7;287(5450):138-42. doi: 10.1126/science.287.5450.138.