PMID- 10613898
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20191023
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 147
IP  - 7
DP  - 1999 Dec 27
TI  - A novel muscle-specific beta 1 integrin binding protein (MIBP) that modulates
      myogenic differentiation.
PG  - 1391-8
AB  - Myogenesis is regulated by cell adhesion receptors, including integrins of the
      beta1 family. We report the identification of a novel muscle-specific beta1
      integrin binding protein (MIBP). MIBP binds to the membrane-proximal cytoplasmic 
      region shared by beta1A and beta1D integrins, and the binding occurs in vivo as
      well as in vitro. Furthermore, we show that MIBP is abundantly expressed by C2C12
      myogenic cells before fusion, and the expression of MIBP is dramatically
      downregulated during subsequent differentiation. Finally, we show that
      overexpression of MIBP in C2C12 cells resulted in a suppression of fusion and
      terminal differentiation, suggesting that MIBP may play a key role in controlling
      the progression of muscle differentiation.
FAU - Li, J
AU  - Li J
AD  - Department of Cell Biology and The Cell Adhesion and Matrix Research Center,
      University of Alabama at Birmingham, Birmingham, Alabama 35294-0019, USA.
FAU - Mayne, R
AU  - Mayne R
FAU - Wu, C
AU  - Wu C
LA  - eng
SI  - GENBANK/AF190819
GR  - DK54639/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Carrier Proteins)
RN  - 0 (Growth Inhibitors)
RN  - 0 (Integrin beta1)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Myogenic Regulatory Factors)
RN  - EC 2.7.1.- (NMRK2 protein, human)
RN  - EC 2.7.1.- (Phosphotransferases (Alcohol Group Acceptor))
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - COS Cells
MH  - Carrier Proteins/biosynthesis/genetics/isolation & purification/*physiology
MH  - Cell Differentiation/genetics
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Cytoplasm/metabolism/physiology
MH  - Down-Regulation
MH  - Growth Inhibitors/biosynthesis/physiology
MH  - Humans
MH  - Integrin beta1/*metabolism
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Membrane Proteins/metabolism/physiology
MH  - Mice
MH  - Molecular Sequence Data
MH  - Muscle, Skeletal/*cytology/metabolism/physiology
MH  - Myogenic Regulatory Factors/genetics/isolation & purification/*physiology
MH  - Organ Specificity/physiology
MH  - Phosphotransferases (Alcohol Group Acceptor)
PMC - PMC2174245
EDAT- 1999/12/30 00:00
MHDA- 1999/12/30 00:01
CRDT- 1999/12/30 00:00
PHST- 1999/12/30 00:00 [pubmed]
PHST- 1999/12/30 00:01 [medline]
PHST- 1999/12/30 00:00 [entrez]
AID - 10.1083/jcb.147.7.1391 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Dec 27;147(7):1391-8. doi: 10.1083/jcb.147.7.1391.