PMID- 10613896
OWN - NLM
STAT- MEDLINE
DCOM- 20000204
LR  - 20191023
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 147
IP  - 7
DP  - 1999 Dec 27
TI  - The eps15 homology (EH) domain-based interaction between eps15 and hrb connects
      the molecular machinery of endocytosis to that of nucleocytosolic transport.
PG  - 1379-84
AB  - The Eps15 homology (EH) module is a protein-protein interaction domain that
      establishes a network of connections involved in various aspects of endocytosis
      and sorting. The finding that EH-containing proteins bind to Hrb (a cellular
      cofactor of the Rev protein) and to the related protein Hrbl raised the
      possibility that the EH network might also influence the so-called Rev export
      pathway, which mediates nucleocytoplasmic transfer of proteins and RNAs. In this 
      study, we demonstrate that Eps15 and Eps15R, two EH-containing proteins,
      synergize with Hrb and Hrbl to enhance the function of Rev in the export pathway.
      In addition, the EH-mediated association between Eps15 and Hrb is required for
      the synergistic effect. The interaction between Eps15 and Hrb occurs in the
      cytoplasm, thus pointing to an unexpected site of action of Hrb, and to a
      possible role of the Eps15-Hrb complex in regulating the stability of Rev.
FAU - Doria, M
AU  - Doria M
AD  - Department of Experimental Oncology, European Institute of Oncology, 20141 Milan,
      Italy.
FAU - Salcini, A E
AU  - Salcini AE
FAU - Colombo, E
AU  - Colombo E
FAU - Parslow, T G
AU  - Parslow TG
FAU - Pelicci, P G
AU  - Pelicci PG
FAU - Di Fiore, P P
AU  - Di Fiore PP
LA  - eng
GR  - D.090/Telethon/Italy
GR  - AI40317/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (AGFG1 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Calcium-Binding Proteins)
RN  - 0 (Eps15-rs protein, mouse)
RN  - 0 (Gene Products, rev)
RN  - 0 (Nuclear Pore Complex Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Phosphoproteins)
RN  - 0 (RNA-Binding Proteins)
SB  - IM
SB  - X
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - Biological Transport
MH  - Calcium-Binding Proteins/*physiology
MH  - Cell Compartmentation/physiology
MH  - Cell Line
MH  - Cell Nucleus/metabolism/*physiology
MH  - Cytosol/*physiology
MH  - Drug Synergism
MH  - *Endocytosis
MH  - Gene Products, rev/*physiology
MH  - *Nuclear Pore Complex Proteins
MH  - Nuclear Proteins/*physiology
MH  - Phosphoproteins/*physiology
MH  - *RNA-Binding Proteins
MH  - Sequence Homology, Amino Acid
MH  - Signal Transduction
PMC - PMC2174238
EDAT- 1999/12/30 00:00
MHDA- 1999/12/30 00:01
CRDT- 1999/12/30 00:00
PHST- 1999/12/30 00:00 [pubmed]
PHST- 1999/12/30 00:01 [medline]
PHST- 1999/12/30 00:00 [entrez]
AID - 10.1083/jcb.147.7.1379 [doi]
PST - ppublish
SO  - J Cell Biol. 1999 Dec 27;147(7):1379-84. doi: 10.1083/jcb.147.7.1379.