PMID- 10612401
OWN - NLM
STAT- MEDLINE
DCOM- 20000118
LR  - 20220321
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 6
DP  - 1999 Dec 10
TI  - Cycling vrille expression is required for a functional Drosophila clock.
PG  - 661-71
AB  - We identified a novel regulatory loop within Drosophila's circadian clock. A
      screen for clock-controlled genes recovered vrille (vri), a transcription factor 
      essential for embryonic development. vri is expressed in circadian pacemaker
      cells in larval and adult brains. vri RNA levels oscillate with a circadian
      rhythm. Cycling is directly regulated by the transcription factors dCLOCK and
      CYCLE, which are also required for oscillations of period and timeless RNA.
      Eliminating the normal vri cycle suppresses period and timeless expression and
      causes long-period behavioral rhythms and arrhythmicity, indicating that cycling 
      vri is required for a functional Drosophila clock. We also show that dCLOCK and
      VRI independently regulate levels of a neuropeptide, pigment dispersing factor,
      which appears to regulate overt behavior.
FAU - Blau, J
AU  - Blau J
AD  - Laboratory of Genetics, The Rockefeller University, New York, New York 10021,
      USA.
FAU - Young, M W
AU  - Young MW
LA  - eng
GR  - GM54339/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (ARNTL Transcription Factors)
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (Clk protein, Drosophila)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
RN  - 0 (cyc protein, Drosophila)
RN  - 0 (vri protein, Drosophila)
RN  - EC 2.3.1.48 (CLOCK Proteins)
SB  - IM
MH  - ARNTL Transcription Factors
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Biological Clocks/*genetics
MH  - Brain/metabolism
MH  - CLOCK Proteins
MH  - Circadian Rhythm/genetics
MH  - Drosophila/embryology/*genetics/metabolism
MH  - *Drosophila Proteins
MH  - Gene Expression Regulation, Developmental
MH  - Insect Proteins/genetics/*metabolism
MH  - Larva
MH  - Trans-Activators/genetics/metabolism
MH  - Transcription Factors/genetics/*metabolism
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - S0092-8674(00)81554-8 [pii]
AID - 10.1016/s0092-8674(00)81554-8 [doi]
PST - ppublish
SO  - Cell. 1999 Dec 10;99(6):661-71. doi: 10.1016/s0092-8674(00)81554-8.