PMID- 10612399
OWN - NLM
STAT- MEDLINE
DCOM- 20000118
LR  - 20190705
IS  - 0092-8674 (Print)
IS  - 0092-8674 (Linking)
VI  - 99
IP  - 6
DP  - 1999 Dec 10
TI  - Proteins of the CNR family are multiple receptors for Reelin.
PG  - 635-47
AB  - Layering and positioning of neurons require Reelin- and Src family-associated
      mammalian Disabled (mDab1). Cadherin-related neuronal receptor (CNR) genes are
      expressed in neurons of the cortical layer, but not in Cajal-Retzius cells
      expressing Reelin. This leads us to hypothesize that CNRs bound to Fyn of the Src
      family are receptors for Reelin. Herein we confirm the association and
      colocalization of CNR proteins with Reelin. This binding is blocked by CR-50
      antibody against Reelin, as well as by monoclonal antibodies produced against
      CNRs. Both disturb the signaling pathway from Reelin to mDab1 and the positioning
      of cortical neurons in vitro. These results strongly suggest that the CNR family 
      proteins are multiple Reelin receptors. In addition, differential conservation of
      the Reelin-binding domain among terrestrial vertebrates may be pertinent to the
      diversity or complexity of brains.
FAU - Senzaki, K
AU  - Senzaki K
AD  - Laboratory of Neurobiology and Behavioral Genetics, National Institute for
      Physiological Sciences, Myodaiji, Okazaki, Japan.
FAU - Ogawa, M
AU  - Ogawa M
FAU - Yagi, T
AU  - Yagi T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cell
JT  - Cell
JID - 0413066
RN  - 0 (Cadherins)
RN  - 0 (Cell Adhesion Molecules, Neuronal)
RN  - 0 (Dab1 protein, mouse)
RN  - 0 (Extracellular Matrix Proteins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Neuropeptides)
RN  - 0 (PCDHA4 protein, human)
RN  - 0 (PCDHA6 protein, human)
RN  - 0 (Pcdha4 protein, mouse)
RN  - 0 (Pcdha4 protein, rat)
RN  - 0 (Pcdha6 protein, mouse)
RN  - 0 (Pcdha6 protein, rat)
RN  - 0 (Receptors, Cell Surface)
RN  - EC 3.4.21.- (Serine Endopeptidases)
RN  - EC 3.4.21.- (reelin protein)
SB  - IM
MH  - Animals
MH  - Cadherins/*metabolism
MH  - Cell Adhesion Molecules, Neuronal/*metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/cytology
MH  - Evolution, Molecular
MH  - Extracellular Matrix Proteins/*metabolism
MH  - Humans
MH  - In Situ Hybridization
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Nerve Tissue Proteins/*metabolism
MH  - Neurons/metabolism
MH  - Neuropeptides/*metabolism
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Rats
MH  - Rats, Inbred F344
MH  - *Receptors, Cell Surface
MH  - Sensory Receptor Cells/*metabolism
MH  - Serine Endopeptidases
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - S0092-8674(00)81552-4 [pii]
AID - 10.1016/s0092-8674(00)81552-4 [doi]
PST - ppublish
SO  - Cell. 1999 Dec 10;99(6):635-47. doi: 10.1016/s0092-8674(00)81552-4.