PMID- 10611478
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 464
IP  - 1-2
DP  - 1999 Dec 24
TI  - Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth.
PG  - 30-4
AB  - The cell adhesion molecules NCAM and L1 are considered to play key roles in
      neuronal development and plasticity. L1 has been shown to interact with NCAM,
      possibly through NCAM binding to oligomannosidic glycans present in L1. We
      investigated the effect of recombinant immunoglobulin (Ig) modules of NCAM
      involved in homophilic NCAM binding, on L1 induced neurite outgrowth from PC12-E2
      cells and found a complete inhibition of L1 induced neurite outgrowth after
      addition of Ig-modules 1, 2 and 3 of NCAM, suggesting that the ligation state of 
      NCAM is crucial for normal L1 signaling.
FAU - Kristiansen, L V
AU  - Kristiansen LV
AD  - Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen,
      Panum Institute, Blegdamsvej 3C, Bld. 6.2, DK-2200, Copenhagen N, Denmark.
FAU - Marques, F A
AU  - Marques FA
FAU - Soroka, V
AU  - Soroka V
FAU - Ronn, L C
AU  - Ronn LC
FAU - Kiselyov, V
AU  - Kiselyov V
FAU - Pedersen, N
AU  - Pedersen N
FAU - Berezin, V
AU  - Berezin V
FAU - Bock, E
AU  - Bock E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Immunoglobulins)
RN  - 0 (Leukocyte L1 Antigen Complex)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Cell Aggregation/drug effects
MH  - Cell Division/drug effects
MH  - Coculture Techniques
MH  - Immunoglobulins/metabolism
MH  - Leukocyte L1 Antigen Complex
MH  - Membrane Glycoproteins/*metabolism
MH  - Mice
MH  - Neural Cell Adhesion Molecules/*metabolism/physiology
MH  - Neurites/*metabolism
MH  - Protein Binding
MH  - Protein Conformation
MH  - Rats
MH  - Recombinant Proteins/metabolism
MH  - Transfection
MH  - Tumor Cells, Cultured
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - S0014-5793(99)01671-3 [pii]
AID - 10.1016/s0014-5793(99)01671-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 24;464(1-2):30-4. doi: 10.1016/s0014-5793(99)01671-3.