PMID- 10611300
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 26
DP  - 1999 Dec 21
TI  - Glucose intolerance caused by a defect in the entero-insular axis: a study in
      gastric inhibitory polypeptide receptor knockout mice.
PG  - 14843-7
AB  - Mice with a targeted mutation of the gastric inhibitory polypeptide (GIP)
      receptor gene (GIPR) were generated to determine the role of GIP as a mediator of
      signals from the gut to pancreatic beta cells. GIPR-/- mice have higher blood
      glucose levels with impaired initial insulin response after oral glucose load.
      Although blood glucose levels after meal ingestion are not increased by high-fat 
      diet in GIPR+/+ mice because of compensatory higher insulin secretion, they are
      significantly increased in GIPR-/- mice because of the lack of such enhancement. 
      Accordingly, early insulin secretion mediated by GIP determines glucose tolerance
      after oral glucose load in vivo, and because GIP plays an important role in the
      compensatory enhancement of insulin secretion produced by a high insulin demand, 
      a defect in this entero-insular axis may contribute to the pathogenesis of
      diabetes.
FAU - Miyawaki, K
AU  - Miyawaki K
AD  - Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto
      606-8507, Japan.
FAU - Yamada, Y
AU  - Yamada Y
FAU - Yano, H
AU  - Yano H
FAU - Niwa, H
AU  - Niwa H
FAU - Ban, N
AU  - Ban N
FAU - Ihara, Y
AU  - Ihara Y
FAU - Kubota, A
AU  - Kubota A
FAU - Fujimoto, S
AU  - Fujimoto S
FAU - Kajikawa, M
AU  - Kajikawa M
FAU - Kuroe, A
AU  - Kuroe A
FAU - Tsuda, K
AU  - Tsuda K
FAU - Hashimoto, H
AU  - Hashimoto H
FAU - Yamashita, T
AU  - Yamashita T
FAU - Jomori, T
AU  - Jomori T
FAU - Tashiro, F
AU  - Tashiro F
FAU - Miyazaki, J
AU  - Miyazaki J
FAU - Seino, Y
AU  - Seino Y
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
RN  - 0 (Peptide Fragments)
RN  - 0 (Protein Precursors)
RN  - 0 (Receptors, Gastrointestinal Hormone)
RN  - 119637-73-9 (glucagon-like peptide 1 (7-36)amide)
RN  - 59392-49-3 (Gastric Inhibitory Polypeptide)
RN  - 62340-29-8 (Glucagon-Like Peptides)
RN  - 89750-14-1 (Glucagon-Like Peptide 1)
RN  - 9007-92-5 (Glucagon)
RN  - D6H00MV7K8 (gastric inhibitory polypeptide receptor)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Administration, Oral
MH  - Animals
MH  - Diabetes Mellitus, Type 2/etiology
MH  - Dietary Fats
MH  - Gastric Inhibitory Polypeptide/metabolism
MH  - Glucagon/metabolism
MH  - Glucagon-Like Peptide 1
MH  - Glucagon-Like Peptides
MH  - Glucose/*pharmacology
MH  - Glucose Intolerance/*genetics
MH  - Glucose Tolerance Test
MH  - Homeostasis/physiology
MH  - Injections, Intraperitoneal
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Insulin Secretion
MH  - Intestines/*physiology
MH  - Islets of Langerhans/*physiology
MH  - Mice
MH  - Mice, Knockout
MH  - Models, Biological
MH  - Peptide Fragments/metabolism
MH  - Protein Precursors/metabolism
MH  - Receptors, Gastrointestinal Hormone/*genetics
PMC - PMC24735
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - 10.1073/pnas.96.26.14843 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14843-7. doi:
      10.1073/pnas.96.26.14843.