PMID- 10611298
OWN - NLM
STAT- MEDLINE
DCOM- 20000127
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 96
IP  - 26
DP  - 1999 Dec 21
TI  - Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general
      mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and
      gammaFBP-B.
PG  - 14831-6
AB  - Hypermethylated in cancer (HIC-1), a new candidate tumor suppressor gene located 
      in 17p13.3, encodes a protein with five C(2)H(2) zinc fingers and an N-terminal
      broad complex, tramtrack, and bric a brac/poxviruses and zinc-finger (BTB/POZ)
      domain found in actin binding proteins or transcriptional regulators involved in 
      chromatin modeling. In the human B cell lymphoma (BCL-6) and promyelocityc
      leukemia (PLZF) oncoproteins, this domain mediates transcriptional repression
      through its ability to recruit a silencing mediator of retinoid and thyroid
      hormone receptor (SMRT)/nuclear receptor corepressor (N-CoR)-mSin3A-histone
      deacetylase (HDAC) complex, a mechanism shared with numerous transcription
      factors. HIC-1 appears unique because it contains a 13-aa insertion acquired late
      in evolution, because it is not found in its avian homologue, gammaF1-binding
      protein isoform B (gammaFBP-B), a transcriptional repressor of the
      gammaF-crystallin gene. This insertion, located in a conserved region involved in
      the dimerization and scaffolding of the BTB/POZ domain, mainly affects slightly
      the ability of the HIC-1 and gammaFBP-B BTB/POZ domains to homo- and
      heterodimerize in vivo, as shown by mammalian two-hybrid experiments. Both the
      HIC-1 and gammaFBP-B BTB/POZ domains behave as autonomous transcriptional
      repression domains. However, in striking contrast with BCL-6 and PLZF, both HIC-1
      and gammaFBP-B similarly fail to interact with members of the HDAC complexes
      (SMRT/N-CoR, mSin3A or HDAC-1) in vivo and in vitro. In addition, a general and
      specific inhibitor of HDACs, trichostatin A, did not alleviate the HIC-1- and
      gammaFBP-B-mediated transcriptional repression, as previously shown for BCL-6.
      Taken together, our studies show that the recruitment onto target promoters of an
      HDAC complex is not a general property of transcriptional repressors containing a
      conserved BTB/POZ domain.
FAU - Deltour, S
AU  - Deltour S
AD  - Centre National de la Recherche Scientifique Unite Mixte de Recherche 8526,
      Institut de Biologie de Lille, Institut Pasteur de Lille, 1 Rue Calmette, 59017
      Lille Cedex, France.
FAU - Guerardel, C
AU  - Guerardel C
FAU - Leprince, D
AU  - Leprince D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (ABTB1 protein, human)
RN  - 0 (Abtb1 protein, mouse)
RN  - 0 (Butyrates)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hic1 protein, mouse)
RN  - 0 (Histone Deacetylase Inhibitors)
RN  - 0 (Hydroxamic Acids)
RN  - 0 (Kruppel-Like Transcription Factors)
RN  - 0 (NCOR1 protein, human)
RN  - 0 (NCOR2 protein, human)
RN  - 0 (Ncor1 protein, mouse)
RN  - 0 (Ncor2 protein, mouse)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Nuclear Receptor Co-Repressor 1)
RN  - 0 (Nuclear Receptor Co-Repressor 2)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (Proto-Oncogene Proteins c-bcl-6)
RN  - 0 (Repressor Proteins)
RN  - 0 (SIN3A transcription factor)
RN  - 0 (Transcription Factors)
RN  - EC 3.5.1.98 (Histone Deacetylases)
SB  - IM
MH  - Animals
MH  - Butyrates/pharmacology
MH  - DNA-Binding Proteins/metabolism
MH  - *Gene Silencing
MH  - *Genes, Tumor Suppressor
MH  - Histone Deacetylase Inhibitors
MH  - Histone Deacetylases/metabolism
MH  - Humans
MH  - Hydroxamic Acids/pharmacology
MH  - Kruppel-Like Transcription Factors
MH  - Nuclear Proteins/metabolism
MH  - Nuclear Receptor Co-Repressor 1
MH  - Nuclear Receptor Co-Repressor 2
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - Proto-Oncogene Proteins/metabolism
MH  - Proto-Oncogene Proteins c-bcl-6
MH  - Rabbits
MH  - Repressor Proteins/*metabolism
MH  - Transcription Factors/*metabolism
MH  - Two-Hybrid System Techniques
PMC - PMC24733
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - 10.1073/pnas.96.26.14831 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1999 Dec 21;96(26):14831-6. doi:
      10.1073/pnas.96.26.14831.