PMID- 1061118
OWN - NLM
STAT- MEDLINE
DCOM- 19760401
LR  - 20190501
IS  - 0027-8424 (Print)
IS  - 0027-8424 (Linking)
VI  - 73
IP  - 1
DP  - 1976 Jan
TI  - Purkinje cell degeneration, a new neurological mutation in the mouse.
PG  - 208-12
AB  - A new autosomal recessive mouse mutation, Purkinje cell degeneration (pcd), is
      described. Mutants exhibit a moderate ataxia beginning at 3 to 4 weeks of age.
      The ataxia results from postnatal degeneration of virtually all cerebellar
      Purkinje cells beginning around 15 to 18 days of age and progressing rapidly over
      the next 2 weeks. In addition to the cerebellar disease there is slow progressive
      degeneration in the retina (photoreceptor cells) and olfactory bulb. Also, adult 
      males have abnormal sperm.
FAU - Mullen, R J
AU  - Mullen RJ
FAU - Eicher, E M
AU  - Eicher EM
FAU - Sidman, R L
AU  - Sidman RL
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
SB  - IM
MH  - Animals
MH  - Ataxia/etiology
MH  - Body Weight
MH  - Cerebellum/pathology
MH  - Fertility
MH  - Genes, Recessive
MH  - Male
MH  - Mice
MH  - *Mutation
MH  - *Nerve Degeneration
MH  - Olfactory Bulb/pathology
MH  - Purkinje Cells/*pathology
MH  - Retina/pathology
MH  - Spermatozoa/pathology
PMC - PMC335870
EDAT- 1976/01/01 00:00
MHDA- 1976/01/01 00:01
CRDT- 1976/01/01 00:00
PHST- 1976/01/01 00:00 [pubmed]
PHST- 1976/01/01 00:01 [medline]
PHST- 1976/01/01 00:00 [entrez]
AID - 10.1073/pnas.73.1.208 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 1976 Jan;73(1):208-12. doi: 10.1073/pnas.73.1.208.