PMID- 10610729
OWN - NLM
STAT- MEDLINE
DCOM- 20000209
LR  - 20161124
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 2
DP  - 1999 Dec 1
TI  - ADAM-TS8, a novel metalloprotease of the ADAM-TS family located on mouse
      chromosome 9 and human chromosome 11.
PG  - 312-5
AB  - A disintegrin-like and metalloprotease domain with thrombospondin type I modules 
      (ADAM-TS) describes a novel family of zinc metalloendopeptidases. Its members
      have a common domain organization, which includes, typically, a
      pre-pro-metalloprotease domain, a disintegrin-like domain, and one or more
      thrombospondin-like (TS) modules. We describe here the complete primary structure
      of mouse ADAM-TS8, through cloning of Adamts8 cDNA. This novel member of the
      family contains two TS modules and is highly similar in sequence and domain
      organization to three other recently described gene products, ADAM-TS5, ADAM-TS6,
      and ADAM-TS7. Adamts8 is expressed at low levels throughout development and in
      adult mouse lung and heart. Through analysis of an interspecific backcross panel,
      we place the Adamts8 locus on mouse chromosome 9 at a consensus position of 11 cM
      and its human ortholog, recently reported as the METH2 gene, on human chromosome 
      11q25.
CI  - Copyright 1999 Academic Press.
FAU - Georgiadis, K E
AU  - Georgiadis KE
AD  - Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic
      Foundation, Cleveland, Ohio 44195, USA.
FAU - Hirohata, S
AU  - Hirohata S
FAU - Seldin, M F
AU  - Seldin MF
FAU - Apte, S S
AU  - Apte SS
LA  - eng
SI  - GENBANK/AF175282
SI  - GENBANK/AF175283
GR  - HGO0734/HG/NHGRI NIH HHS/United States
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Thrombospondins)
RN  - EC 3.4.24.- (ADAM Proteins)
RN  - EC 3.4.24.- (ADAMTS Proteins)
RN  - EC 3.4.24.- (ADAMTS5 Protein)
RN  - EC 3.4.24.- (ADAMTS5 protein, human)
RN  - EC 3.4.24.- (ADAMTS8 protein, human)
RN  - EC 3.4.24.- (Adamts5 protein, mouse)
RN  - EC 3.4.24.- (Adamts8 protein, mouse)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - J41CSQ7QDS (Zinc)
RN  - K848JZ4886 (Cysteine)
SB  - IM
MH  - ADAM Proteins
MH  - ADAMTS Proteins
MH  - ADAMTS5 Protein
MH  - Amino Acid Sequence
MH  - Animals
MH  - Blotting, Northern
MH  - Chromosomes, Human, Pair 11/*genetics
MH  - Cysteine/chemistry
MH  - Humans
MH  - Metalloendopeptidases/biosynthesis/chemistry/*genetics
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Protein Binding
MH  - Protein Structure, Tertiary
MH  - *Sequence Homology, Amino Acid
MH  - Thrombospondins/chemistry
MH  - Zinc/metabolism
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - 10.1006/geno.1999.6014 [doi]
AID - S0888-7543(99)96014-7 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 1;62(2):312-5. doi: 10.1006/geno.1999.6014.