PMID- 10610721
OWN - NLM
STAT- MEDLINE
DCOM- 20000209
LR  - 20181130
IS  - 0888-7543 (Print)
IS  - 0888-7543 (Linking)
VI  - 62
IP  - 2
DP  - 1999 Dec 1
TI  - Isolation and characterization of human and mouse ZIRTL, a member of the IRT1
      family of transporters, mapping within the epidermal differentiation complex.
PG  - 272-80
AB  - We report the precise mapping and characterization of ZIRTL (zinc-iron regulated 
      transporter-like) gene, the first mammalian member of an extensive family of
      divalent metal ion transporters, comprising IRT1 and ZIP1, ZIP2, ZIP3, and ZIP4
      in plants and ZRT1 and ZRT2 in yeast. The human gene maps at the telomeric end of
      the epidermal differentiation complex (EDC), within chromosomal band 1q21, while 
      the mouse gene maps within the mouse EDC, on mouse chromosome 3, between S100A9
      and S100A13. The structure of the human gene has been determined, and message was
      detected in most adult and fetal tissues including the epidermis. The mouse gene 
      is developmentally regulated and found expressed in fetal and adult suprabasal
      epidermis, osteoblasts, small intestine, and salivary gland.
CI  - Copyright 1999 Academic Press.
FAU - Lioumi, M
AU  - Lioumi M
AD  - Division of Medical and Molecular Genetics, Department of Craniofacial
      Development, The Guy's, King's College and St. Thomas' Hospitals' Medical and
      Dental School, London, United Kingdom. m.lioumi@umds.ac.uk
FAU - Ferguson, C A
AU  - Ferguson CA
FAU - Sharpe, P T
AU  - Sharpe PT
FAU - Freeman, T
AU  - Freeman T
FAU - Marenholz, I
AU  - Marenholz I
FAU - Mischke, D
AU  - Mischke D
FAU - Heizmann, C
AU  - Heizmann C
FAU - Ragoussis, J
AU  - Ragoussis J
LA  - eng
SI  - GENBANK/AJ243649
SI  - GENBANK/AJ243650
SI  - GENBANK/AJ243651
GR  - G9800001/Medical Research Council/United Kingdom
GR  - Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Genomics
JT  - Genomics
JID - 8800135
RN  - 0 (Carrier Proteins)
RN  - 0 (Cation Transport Proteins)
RN  - 0 (DNA, Complementary)
RN  - 0 (SLC39A1 protein, human)
RN  - 0 (Slc39a1 protein, mouse)
RN  - E1UOL152H7 (Iron)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Carrier Proteins/biosynthesis/chemistry/genetics/*isolation & purification
MH  - *Cation Transport Proteins
MH  - Cell Differentiation/genetics
MH  - Chromosomes, Human, Pair 1/genetics
MH  - Cloning, Molecular
MH  - DNA, Complementary/chemistry/isolation & purification
MH  - *Epidermal Cells
MH  - Epidermis/*metabolism
MH  - Exons
MH  - Gene Expression Regulation, Developmental
MH  - Humans
MH  - In Situ Hybridization
MH  - Introns
MH  - Iron/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - *Multigene Family
MH  - Organ Specificity/genetics
MH  - *Sequence Homology, Amino Acid
MH  - Zinc/metabolism
EDAT- 1999/12/28 00:00
MHDA- 1999/12/28 00:01
CRDT- 1999/12/28 00:00
PHST- 1999/12/28 00:00 [pubmed]
PHST- 1999/12/28 00:01 [medline]
PHST- 1999/12/28 00:00 [entrez]
AID - 10.1006/geno.1999.5993 [doi]
AID - S0888-7543(99)95993-1 [pii]
PST - ppublish
SO  - Genomics. 1999 Dec 1;62(2):272-80. doi: 10.1006/geno.1999.5993.