PMID- 10609087 OWN - NLM STAT- MEDLINE DCOM- 20000113 LR - 20191103 IS - 0764-4469 (Print) IS - 0764-4469 (Linking) VI - 322 IP - 10 DP - 1999 Oct TI - Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice. PG - 831-6 AB - Genes implicated in consumption of a bitter compound, sucrose octaacetate (SOA), were investigated using a full genomic scanning strategy. For a 0.1 mM concentration, two QTL reached 5.8 and 6.5 lod scores on chromosomes 2 (77 cM) and 11 (14 cM), respectively. For a 1 mM concentration, the Soa linkage on chromosome 6 (58 cM, lod score 9.4) was replicated, and another QTL was found on chromosome 19 (15 cM, lod score 3.2). Candidacy of previously identified genes in the close vicinity of the peak of the QTL was examined. FAU - Le Roy, I AU - Le Roy I AD - UPR CNRS 9074, Genetique, neurogenetique, comportement, Institut de transgenose, Orleans, France. FAU - Pager, J AU - Pager J FAU - Roubertoux, P L AU - Roubertoux PL LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - France TA - C R Acad Sci III JT - Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie JID - 8503078 RN - 07V591057T (sucrose octaacetate) RN - 57-50-1 (Sucrose) SB - IM MH - Animals MH - Chromosome Mapping MH - Female MH - Genetic Linkage MH - Male MH - Mice MH - Mice, Inbred C57BL MH - Mice, Inbred NZB MH - Polymorphism, Genetic MH - Sucrose/*analogs & derivatives MH - Taste/*genetics EDAT- 1999/12/28 00:00 MHDA- 1999/12/28 00:01 CRDT- 1999/12/28 00:00 PHST- 1999/12/28 00:00 [pubmed] PHST- 1999/12/28 00:01 [medline] PHST- 1999/12/28 00:00 [entrez] AID - S0764446900866470 [pii] AID - 10.1016/s0764-4469(00)86647-0 [doi] PST - ppublish SO - C R Acad Sci III. 1999 Oct;322(10):831-6. doi: 10.1016/s0764-4469(00)86647-0.