PMID- 10608802
OWN - NLM
STAT- MEDLINE
DCOM- 20000208
LR  - 20190508
IS  - 0021-9258 (Print)
IS  - 0021-9258 (Linking)
VI  - 274
IP  - 53
DP  - 1999 Dec 31
TI  - The new kallikrein-like gene, KLK-L2. Molecular characterization, mapping, tissue
      expression, and hormonal regulation.
PG  - 37511-6
AB  - Since in rodents the kallikreins are represented by a large multi-gene family,
      the restriction of this family in humans to three genes is somewhat surprising.
      In an effort to identify new human kallikrein genes, we examined a genomic area
      of about 300 kilobases on chromosome 19q13.3-q13.4, a region that contains most
      of the currently known kallikreins. By using the positional candidate approach,
      we were able to identify a new gene named KLK-L2 (for kallikrein- like gene 2).
      Screening of human EST libraries allowed us to delineate the full genomic and
      cDNA structure of the new gene. KLK-L2 consists of 5 coding exons and 4 introns
      and has significant similarities to other members of the kallikrein multi-gene
      family. Homology studies suggest that the protein is likely secreted. KLK-L2 is
      expressed mainly in breast, brain, and testis and to a lesser extent in many
      other tissues. KLK-L2 is up-regulated by estrogens and progestins in the breast
      cancer cell line BT-474.
FAU - Yousef, G M
AU  - Yousef GM
AD  - Department of Pathology, Mount Sinai Hospital, Toronto M5G 1X5, Toronto, Ontario 
      M5G 1L5, Canada.
FAU - Diamandis, E P
AU  - Diamandis EP
LA  - eng
SI  - GENBANK/AF135028
PT  - Journal Article
PL  - United States
TA  - J Biol Chem
JT  - The Journal of biological chemistry
JID - 2985121R
RN  - EC 3.4.21.- (Kallikreins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 19
MH  - Expressed Sequence Tags
MH  - Humans
MH  - Kallikreins/*genetics
MH  - Molecular Sequence Data
MH  - Multigene Family
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Homology, Amino Acid
EDAT- 1999/12/23 00:00
MHDA- 1999/12/23 00:01
CRDT- 1999/12/23 00:00
PHST- 1999/12/23 00:00 [pubmed]
PHST- 1999/12/23 00:01 [medline]
PHST- 1999/12/23 00:00 [entrez]
AID - 10.1074/jbc.274.53.37511 [doi]
PST - ppublish
SO  - J Biol Chem. 1999 Dec 31;274(53):37511-6. doi: 10.1074/jbc.274.53.37511.