PMID- 10608765
OWN - NLM
STAT- MEDLINE
DCOM- 20000303
LR  - 20071114
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 181
IP  - 1
DP  - 2000 Jan
TI  - Cerebral cell adhesion molecule: a novel leukocyte adhesion determinant on
      blood-brain barrier capillary endothelium.
PG  - 181-7
AB  - The tight junctions of the cerebral capillary endothelium form the highly
      restrictive blood-brain barrier. Migration of leukocytes across this unique
      barrier may involve ligation of elements in addition to those of the fenestrated 
      capillaries of the peripheral vascular system. An antibody raised against a
      bacterial adhesive protein and shown to have cross-reactivity with brain
      capillaries and to block leukocyte migration into the brain was used to identify 
      and clone a novel determinant on brain microvessels. This cDNA was sequenced, and
      the expressed protein supported leukocyte adhesion in a CD18-dependent fashion.
      The high level of brain microvessel expression of this adhesion molecule, termed 
      the cerebral cell adhesion molecule, implicates it in leukocyte transmigration
      across the blood-brain barrier.
FAU - Starzyk, R M
AU  - Starzyk RM
AD  - Alkermes, Inc., Cambridge, Massachusetts, USA.
FAU - Rosenow, C
AU  - Rosenow C
FAU - Frye, J
AU  - Frye J
FAU - Leismann, M
AU  - Leismann M
FAU - Rodzinski, E
AU  - Rodzinski E
FAU - Putney, S
AU  - Putney S
FAU - Tuomanen, E I
AU  - Tuomanen EI
LA  - eng
GR  - AI-23459/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Adhesins, Bacterial)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Hemagglutinins)
RN  - 0 (Virulence Factors, Bordetella)
RN  - 0 (filamentous hemagglutinin adhesin, Bordetella pertussis)
SB  - AIM
SB  - IM
MH  - Adhesins, Bacterial/immunology
MH  - *Blood-Brain Barrier
MH  - *Capillaries
MH  - Cell Adhesion
MH  - Cell Adhesion Molecules/*immunology/isolation & purification
MH  - Cerebral Cortex/*blood supply
MH  - *Endothelium, Vascular
MH  - Hemagglutinins/immunology
MH  - Humans
MH  - Neutrophils/physiology
MH  - Tight Junctions
MH  - Tissue Distribution
MH  - *Virulence Factors, Bordetella
EDAT- 1999/12/23 09:00
MHDA- 2000/03/21 09:00
CRDT- 1999/12/23 09:00
PHST- 1999/12/23 09:00 [pubmed]
PHST- 2000/03/21 09:00 [medline]
PHST- 1999/12/23 09:00 [entrez]
AID - JID981253 [pii]
AID - 10.1086/315163 [doi]
PST - ppublish
SO  - J Infect Dis. 2000 Jan;181(1):181-7. doi: 10.1086/315163.