PMID- 10607842
OWN - NLM
STAT- MEDLINE
DCOM- 20000228
LR  - 20190513
IS  - 0964-6906 (Print)
IS  - 0964-6906 (Linking)
VI  - 9
IP  - 2
DP  - 2000 Jan 22
TI  - A human sex-chromosomal gene family expressed in male germ cells and encoding
      variably charged proteins.
PG  - 311-9
AB  - Approximately 12 X-Y homologous gene pairs have been identified in the
      non-recombining portions of human sex chromosomes. These X-Y gene pairs fall into
      two categories. In the first category, both X and Y homologs are ubiquitously
      expressed. In the second category, the X homolog is ubiquitously expressed,
      whereas the Y homolog is expressed exclusively in the testis. Here we describe a 
      family of human X-Y genes that cannot be assigned to either category. Designated 
      VCX / Y ( Variable Charge X / Y; VCY previously known as BPY1 ), this gene family
      has multiple members on both X and Y, and all appear to be expressed exclusively 
      in male germ cells. Members of the VCX / Y family share a high degree of sequence
      identity, with the exception that a 30 nucleotide unit is tandemly repeated in
      X-linked members but is present only once in Y-linked members. These atypical
      features suggest that the VCX / Y family has evolved in a manner previously
      unrecognized for mammalian X-Y genes. We also found that a copy of VCX is present
      in CRI-S232, a previously described genomic fragment derived from the X
      chromosome. Studies have shown that aberrant recombination between arrays of
      CRI-S232-homologous repeats flanking the steroid sulfatase ( STS ) gene results
      in STS deletion, which is manifested clinically as X-linked ichthyosis. The
      revelation that CRI-S232 contains VCX offers a more precise description of the
      genetic etiology of X-linked ichthyosis: it results from aberrant recombination
      between VCX gene arrays that flank the STS locus.
FAU - Lahn, B T
AU  - Lahn BT
AD  - Howard Hughes Medical Institute, Whitehead Institute and Department of Biology,
      Massachusetts Institute of Technology, 9 Cambridge Center, Cambridge, MA 02142,
      USA. blahn@genetics-uchicago.edu
FAU - Page, D C
AU  - Page DC
LA  - eng
SI  - GENBANK/AF000979
SI  - GENBANK/AF159127
SI  - GENBANK/AF159128
SI  - GENBANK/AF159129
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Hum Mol Genet
JT  - Human molecular genetics
JID - 9208958
RN  - 0 (Nuclear Proteins)
RN  - 0 (VCX protein, human)
RN  - 0 (VCY protein, human)
SB  - IM
MH  - Adult
MH  - Amino Acid Sequence
MH  - Base Sequence
MH  - Gene Expression Regulation, Developmental/*genetics
MH  - Humans
MH  - Male
MH  - Molecular Sequence Data
MH  - Multigene Family/*genetics
MH  - Nuclear Proteins/*biosynthesis/genetics
MH  - Pedigree
MH  - Spermatozoa/*metabolism
MH  - X Chromosome/*genetics
MH  - Y Chromosome/*genetics
EDAT- 1999/12/23 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/23 09:00
PHST- 1999/12/23 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/23 09:00 [entrez]
AID - ddd031 [pii]
AID - 10.1093/hmg/9.2.311 [doi]
PST - ppublish
SO  - Hum Mol Genet. 2000 Jan 22;9(2):311-9. doi: 10.1093/hmg/9.2.311.