PMID- 10607749
OWN - NLM
STAT- MEDLINE
DCOM- 20000224
LR  - 20190513
IS  - 0953-8178 (Print)
IS  - 0953-8178 (Linking)
VI  - 12
IP  - 1
DP  - 2000 Jan
TI  - AILIM/ICOS: a novel lymphocyte adhesion molecule.
PG  - 51-5
AB  - The adhesive interaction between T cells and antigen-presenting cells is required
      for the formation of the immunological synapse. Inducible co-stimulator (ICOS) is
      a third member of the CD28 family of co-stimulatory molecules. Here we describe a
      novel lymphocyte adhesion molecule, of relative molecular mass 47,000, designated
      AILIM, that is a rat homolog of ICOS. Rat AILIM was constitutively expressed on
      thymocytes and was induced on naive T cells after activation. Human thymoma cells
      bound to purified AILIM. Furthermore, cells transfected with the AILIM gene
      aggregated in an AILIM-dependent manner. These results suggest a novel function
      for AILIM/ICOS as an adhesion molecule, which plays an important role in T cell
      activation.
FAU - Tamatani, T
AU  - Tamatani T
AD  - Pharmaceutical Frontier Research Laboratories, JT Inc., 1-13-2 Fukuura,
      Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
FAU - Tezuka, K
AU  - Tezuka K
FAU - Hanzawa-Higuchi, N
AU  - Hanzawa-Higuchi N
LA  - eng
SI  - GENBANK/AB023134
PT  - Journal Article
PL  - England
TA  - Int Immunol
JT  - International immunology
JID - 8916182
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Antigens, Differentiation, T-Lymphocyte)
RN  - 0 (CD28 Antigens)
RN  - 0 (ICOS protein, human)
RN  - 0 (Icos protein, mouse)
RN  - 0 (Icos protein, rat)
RN  - 0 (Inducible T-Cell Co-Stimulator Protein)
RN  - 0 (Recombinant Proteins)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/pharmacology
MH  - Antigen Presentation
MH  - Antigens, Differentiation, T-Lymphocyte/genetics
MH  - CD28 Antigens/genetics
MH  - Cell Adhesion/drug effects
MH  - Humans
MH  - Inducible T-Cell Co-Stimulator Protein
MH  - *Lymphocyte Activation
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Molecular Sequence Data
MH  - Rats
MH  - Recombinant Proteins/metabolism
MH  - T-Lymphocytes/*immunology
MH  - Thymus Gland/cytology
EDAT- 1999/12/23 09:00
MHDA- 2000/02/26 09:00
CRDT- 1999/12/23 09:00
PHST- 1999/12/23 09:00 [pubmed]
PHST- 2000/02/26 09:00 [medline]
PHST- 1999/12/23 09:00 [entrez]
AID - 10.1093/intimm/12.1.51 [doi]
PST - ppublish
SO  - Int Immunol. 2000 Jan;12(1):51-5. doi: 10.1093/intimm/12.1.51.