PMID- 10607391
OWN - NLM
STAT- MEDLINE
DCOM- 20000124
LR  - 20131121
IS  - 1097-6256 (Print)
IS  - 1097-6256 (Linking)
VI  - 3
IP  - 1
DP  - 2000 Jan
TI  - Collybistin, a newly identified brain-specific GEF, induces submembrane
      clustering of gephyrin.
PG  - 22-9
AB  - The formation of postsynaptic GABAA and glycine receptor clusters requires the
      receptor-associated peripheral membrane protein gephyrin. Here we describe two
      splice variants of a novel gephyrin-binding protein, termed collybistin I and II,
      which belong to the family of dbl-like GDP/GTP exchange factors (GEFs).
      Co-expression of collybistin II with gephyrin induced the formation of
      submembrane gephyrin aggregates that accumulate hetero-oligomeric glycine
      receptors. Our data suggest that collybistin II regulates the membrane deposition
      of gephyrin by activating a GTPase of the Rho/Rac family. Therefore, this protein
      may be an important determinant of inhibitory postsynaptic membrane formation and
      plasticity.
FAU - Kins, S
AU  - Kins S
AD  - Department of Neurochemistry, Max-Planck-Institute for Brain Research,
      Deutschordenstr. 46, D-60528 Frankfurt, Germany.
FAU - Betz, H
AU  - Betz H
FAU - Kirsch, J
AU  - Kirsch J
LA  - eng
SI  - GENBANK/AJ250425
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Nat Neurosci
JT  - Nature neuroscience
JID - 9809671
RN  - 0 (ARHGEF9 protein, human)
RN  - 0 (Arhgef9 protein, rat)
RN  - 0 (Carrier Proteins)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Membrane Proteins)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Glycine)
RN  - 0 (Rho Guanine Nucleotide Exchange Factors)
RN  - 0 (gephyrin)
RN  - EC 3.6.1.- (GTP Phosphohydrolases)
SB  - IM
CIN - Nat Neurosci. 2000 Jan;3(1):5-6. PMID: 10607386
MH  - Alternative Splicing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Brain/*metabolism
MH  - Carrier Proteins/*metabolism
MH  - Cell Line
MH  - Conserved Sequence
MH  - GTP Phosphohydrolases/metabolism
MH  - Guanine Nucleotide Exchange Factors/genetics/*physiology
MH  - Humans
MH  - Macromolecular Substances
MH  - Membrane Proteins/*metabolism
MH  - Molecular Sequence Data
MH  - Organ Specificity
MH  - Protein Isoforms/metabolism/physiology
MH  - Rats
MH  - Receptors, Glycine/metabolism
MH  - Rho Guanine Nucleotide Exchange Factors
MH  - Sequence Homology, Amino Acid
MH  - Synapses/metabolism
MH  - Synaptic Membranes/*metabolism
MH  - src Homology Domains
EDAT- 1999/12/22 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/12/22 09:00
PHST- 1999/12/22 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/12/22 09:00 [entrez]
AID - 10.1038/71096 [doi]
PST - ppublish
SO  - Nat Neurosci. 2000 Jan;3(1):22-9. doi: 10.1038/71096.