PMID- 10606752
OWN - NLM
STAT- MEDLINE
DCOM- 20000119
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 463
IP  - 3
DP  - 1999 Dec 17
TI  - The mammalian Fizzy and Fizzy-related genes are regulated at the transcriptional 
      and post-transcriptional levels.
PG  - 350-4
AB  - The cyclosome pathway of ubiquitin-mediated proteolysis plays an essential role
      in cell cycle control. The multisubunit cyclosome is regulated by transient
      interactions with Fizzy (Fzy) and Fizzy-related (Fzr) genes. We report here that 
      both Fzy and Fzr are transcribed in a cell cycle specific but distinct manner.
      Fzy transcription starts after the restriction point in late G1 and ceases upon
      cell division. Fzr transcription also ceases upon cell division but resumes
      already in mid G1, before the restriction point, and takes place also in G0. Fzr 
      has further a striking cell cycle specific pattern of mRNA stability. During most
      of the cell cycle its message is fairly stable, however upon exit from mitosis it
      is rapidly degraded. This result is puzzling because Fzr is essential for
      cyclosome activity in G1, and points to a complex pattern of Fzr regulation.
FAU - Inbal, N
AU  - Inbal N
AD  - Department of Genetics, The Institute of Life Sciences, The Hebrew University of 
      Jerusalem, Jerusalem, Israel.
FAU - Listovsky, T
AU  - Listovsky T
FAU - Brandeis, M
AU  - Brandeis M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (Cdh1 Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Fzr1 protein, mouse)
RN  - 0 (Insect Proteins)
RN  - 0 (RNA, Messenger)
RN  - 1CC1JFE158 (Dactinomycin)
RN  - SH1WY3R615 (Nocodazole)
SB  - IM
MH  - 3T3 Cells
MH  - Animals
MH  - Cdh1 Proteins
MH  - Cell Cycle Proteins/biosynthesis/*genetics/metabolism
MH  - Cell Division/genetics
MH  - Dactinomycin
MH  - Gene Expression Regulation
MH  - Immunoblotting
MH  - Insect Proteins/genetics
MH  - Mice
MH  - Nocodazole
MH  - RNA, Messenger/isolation & purification/metabolism
MH  - Time Factors
MH  - Transcription, Genetic
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - S0014-5793(99)01640-3 [pii]
AID - 10.1016/s0014-5793(99)01640-3 [doi]
PST - ppublish
SO  - FEBS Lett. 1999 Dec 17;463(3):350-4. doi: 10.1016/s0014-5793(99)01640-3.