PMID- 10605025
OWN - NLM
STAT- MEDLINE
DCOM- 20000119
LR  - 20190515
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 164
IP  - 1
DP  - 2000 Jan 1
TI  - Anergic T lymphocytes selectively express an integrin regulatory protein of the
      cytohesin family.
PG  - 308-18
AB  - It has been proposed that the maintenance of T cell anergy depends on the
      induction of negative regulatory factors. Differential display of reverse
      transcribed RNA was used to identify novel genes that might mediate this function
      in anergic Th1 clones. We report that anergic Th1 clones do indeed express a
      genetic program different from that of responsive T cells. Moreover, one gene,
      the general receptor of phosphoinositides 1 (GRP1), was selectively induced in
      anergic T cells. The GRP1, located in the plasma membrane, regulated
      integrin-mediated adhesion and was invariably associated with unresponsiveness in
      multiple models of anergy. T cells expressing retrovirally transduced GRP1
      exhibited normal proliferation and cytokine production. However, GRP1-transduced 
      T cells were not stable and rapidly lost GRP1 expression. Thus, although GRP1 may
      not directly mediate T cell anergy, it regulates cell expansion and survival,
      perhaps through its integrin-associated activities.
FAU - Korthauer, U
AU  - Korthauer U
AD  - Ben May Institute for Cancer Research, University of Chicago, IL 60637, USA.
FAU - Nagel, W
AU  - Nagel W
FAU - Davis, E M
AU  - Davis EM
FAU - Le Beau, M M
AU  - Le Beau MM
FAU - Menon, R S
AU  - Menon RS
FAU - Mitchell, E O
AU  - Mitchell EO
FAU - Kozak, C A
AU  - Kozak CA
FAU - Kolanus, W
AU  - Kolanus W
FAU - Bluestone, J A
AU  - Bluestone JA
LA  - eng
SI  - GENBANK/AF084221
GR  - CA40046/CA/NCI NIH HHS/United States
GR  - P01AI35294-6/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Antibodies)
RN  - 0 (CD3 Complex)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (Guanine Nucleotide Exchange Factors)
RN  - 0 (Integrins)
RN  - 0 (Lymphocyte Function-Associated Antigen-1)
RN  - 0 (Phosphatidylinositols)
RN  - 0 (Receptors, Antigen, T-Cell)
RN  - 0 (Receptors, Cytoplasmic and Nuclear)
RN  - 0 (cytohesin-1)
RN  - 0 (phosphatidylinositol receptors)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antibodies/pharmacology
MH  - CD3 Complex/immunology
MH  - Cell Adhesion/immunology
MH  - Cell Adhesion Molecules/*biosynthesis
MH  - Cell Membrane/immunology/metabolism
MH  - Chromosome Mapping
MH  - *Clonal Anergy/genetics
MH  - Clone Cells
MH  - Gene Expression Regulation/immunology
MH  - Guanine Nucleotide Exchange Factors
MH  - Integrins/*physiology
MH  - Intercellular Adhesion Molecule-1/physiology
MH  - Lymphocyte Function-Associated Antigen-1/physiology
MH  - Mice
MH  - Mice, Inbred A
MH  - Mice, Inbred DBA
MH  - Mice, Transgenic
MH  - Molecular Sequence Data
MH  - Phosphatidylinositols/metabolism
MH  - Receptors, Antigen, T-Cell/antagonists & inhibitors
MH  - Receptors, Cytoplasmic and Nuclear/*biosynthesis/genetics/isolation &
      purification
MH  - T-Lymphocyte Subsets/*immunology/*metabolism
MH  - Th1 Cells/immunology/metabolism
MH  - Transfection
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - ji_v164n1p308 [pii]
AID - 10.4049/jimmunol.164.1.308 [doi]
PST - ppublish
SO  - J Immunol. 2000 Jan 1;164(1):308-18. doi: 10.4049/jimmunol.164.1.308.