PMID- 10604985
OWN - NLM
STAT- MEDLINE
DCOM- 20000119
LR  - 20190515
IS  - 0022-1767 (Print)
IS  - 0022-1767 (Linking)
VI  - 164
IP  - 1
DP  - 2000 Jan 1
TI  - Cutting edge: signal-regulatory protein beta 1 is a DAP12-associated activating
      receptor expressed in myeloid cells.
PG  - 9-12
AB  - Signal-regulatory proteins (SIRPs) are cell-surface glycoproteins expressed on
      myeloid and neural cells that have been shown to recruit SH2 domain-containing
      protein phosphatase 1 (SHP-1) and SHP-2 and to regulate receptor tyrosine
      kinase-coupled signaling. One SIRP of unknown function, designated SIRP beta 1,
      contains a short cytoplasmic domain that lacks sequence motifs capable of
      recruiting SHP-1 and SHP-2. Using a SIRP-specific mAb, we show that SIRP beta 1
      is expressed in monocytes and dendritic cells and associates with the signal
      transduction molecule DAP12. SIRP beta 1/DAP12 complex formation was required for
      efficient cell-surface expression of SIRP beta 1. Stimulation of this complex
      induced tyrosine phosphorylation, mitogen-activated protein kinase activation,
      and cellular activation. Thus, SIRP beta 1 is a new DAP12-associated receptor
      involved in the activation of myeloid cells.
FAU - Dietrich, J
AU  - Dietrich J
AD  - Basel Institute for Immunology, Basel, Switzerland. vader@biobase.dk
FAU - Cella, M
AU  - Cella M
FAU - Seiffert, M
AU  - Seiffert M
FAU - Buhring, H J
AU  - Buhring HJ
FAU - Colonna, M
AU  - Colonna M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Immunol
JT  - Journal of immunology (Baltimore, Md. : 1950)
JID - 2985117R
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Antigens, Differentiation)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Neural Cell Adhesion Molecule L1)
RN  - 0 (Neural Cell Adhesion Molecules)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (SIRPB1 protein, human)
RN  - 0 (TYROBP protein, human)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - AIM
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Animals
MH  - *Antigens, Differentiation
MH  - Cell Line
MH  - Dendritic Cells/*metabolism
MH  - Humans
MH  - Jurkat Cells
MH  - Membrane Glycoproteins/*biosynthesis/*metabolism/physiology
MH  - Membrane Proteins
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3
MH  - Mitogen-Activated Protein Kinases/metabolism
MH  - Molecular Weight
MH  - Monocytes/*metabolism
MH  - *Neural Cell Adhesion Molecule L1
MH  - Neural Cell Adhesion Molecules/*biosynthesis/*metabolism/physiology
MH  - Phosphorylation
MH  - Receptors, Cell Surface
MH  - Receptors, Immunologic/*metabolism/physiology
MH  - Signal Transduction/*immunology
MH  - U937 Cells
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - ji_v164n1p9 [pii]
AID - 10.4049/jimmunol.164.1.9 [doi]
PST - ppublish
SO  - J Immunol. 2000 Jan 1;164(1):9-12. doi: 10.4049/jimmunol.164.1.9.