PMID- 10604543
OWN - NLM
STAT- MEDLINE
DCOM- 20000229
LR  - 20190921
IS  - 0162-3109 (Print)
IS  - 0162-3109 (Linking)
VI  - 44
IP  - 1-2
DP  - 1999 Oct 15
TI  - Tissue kallikrein and kinins in renal disease.
PG  - 183-92
AB  - The renal kallikrein-kinin system is involved in sodium and water homeostasis,
      blood pressure regulation and inflammation. Tissue kallikrein and kinin levels
      were measured in the urine of patients with renal disease and in the urine of
      living related kidney donors prior to uninephrectomy who served as controls.
      Tissue kallikrein and kinin B1 and B2 receptors were immunolocalised by confocal 
      microscopy in renal biopsy material from patients with renal disease and controls
      (fresh autopsy material and normal kidney tissue from nephrectomies for
      malignancy). Urinary tissue kallikrein excretion was significantly decreased in
      patients with mild renal disease (16.6 +/- 6.7 ng tissue kallikrein (TK)/ng
      protein; p < 0.05) and more markedly so (1.8 +/- 0.7 ng TK/microg protein; p <
      0.01) in patients with severe renal failure requiring dialysis compared to normal
      controls (78.9 +/- 31.7 ng TK/microg protein). Basal kinin values were unchanged 
      in patients with renal disease (14 +/- 0.8 ng/ml) compared to controls (13.3 +/- 
      0.56 ng/ml). In control kidney tissue kallikrein was immunolocalised in the
      distal connecting tubules and collecting ducts whereas decreased immunolabelling 
      was observed with renal disease. Kinin B2 receptor labelling was present in the
      entire nephron in the normal control kidney but was reduced with renal disease.
      While kinin B1 receptor immunolabelling was not observed in the control kidneys, 
      labelling of distal tubules and collecting ducts was noted in renal disease,
      suggesting an upregulation of B1 receptors in renal parenchymal disease.
FAU - Naicker, S
AU  - Naicker S
AD  - Department of Medicine, University of Natal Medical School, Durban, South Africa.
FAU - Naidoo, S
AU  - Naidoo S
FAU - Ramsaroop, R
AU  - Ramsaroop R
FAU - Moodley, D
AU  - Moodley D
FAU - Bhoola, K
AU  - Bhoola K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunopharmacology
JT  - Immunopharmacology
JID - 7902474
RN  - 0 (Kinins)
RN  - 0 (Receptors, Bradykinin)
RN  - EC 3.4.21.35 (Tissue Kallikreins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Female
MH  - Humans
MH  - Kidney Diseases/*metabolism/physiopathology/urine
MH  - Kinins/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Receptors, Bradykinin/metabolism
MH  - Tissue Kallikreins/*metabolism/urine
EDAT- 1999/12/22 09:00
MHDA- 2000/03/04 09:00
CRDT- 1999/12/22 09:00
PHST- 1999/12/22 09:00 [pubmed]
PHST- 2000/03/04 09:00 [medline]
PHST- 1999/12/22 09:00 [entrez]
AID - S0162-3109(99)00089-2 [pii]
AID - 10.1016/s0162-3109(99)00089-2 [doi]
PST - ppublish
SO  - Immunopharmacology. 1999 Oct 15;44(1-2):183-92. doi:
      10.1016/s0162-3109(99)00089-2.