PMID- 10604301
OWN - NLM
STAT- MEDLINE
DCOM- 19991222
LR  - 20071114
IS  - 1057-0829 (Print)
IS  - 1057-0829 (Linking)
VI  - 8
IP  - 6
DP  - 1999 Dec
TI  - Mouse genetics: a tool to help unlock the mechanisms of glaucoma.
PG  - 400-12
AB  - Gene characterization holds great promise for understanding molecular mechanisms 
      of disease. Although glaucoma gene identification is very valuable and allows
      assessment of an individual's genetic risk, it is not by itself sufficient to
      answer detailed questions about pathogenesis. Despite the recent identification
      of a number of glaucoma genes, there are still many questions regarding the ways 
      in which mutations in these genes cause disease. The mouse system, including the 
      ability to alter specific genes, provides a powerful experimental system for
      hypothesis testing and molecular dissection of pathogenesis subsequent to gene
      identification. The ability to control both genetic and environmental factors
      will allow the use of mice to identify modifier genes that alter complex glaucoma
      phenotypes and that are especially difficult to identify in human families. By
      providing a bridge between gene identification and tests of gene function, mouse 
      studies will be an important complement to those in humans and other species.
      This article summarizes the recent use of mice and the future potential of
      applying approaches of mouse genetics to intraocular pressure and glaucoma
      research.
FAU - John, S W
AU  - John SW
AD  - Howard Hughes Medical Institute and The Jackson Laboratory, Bar Harbor, Maine
      04609, USA.
FAU - Anderson, M G
AU  - Anderson MG
FAU - Smith, R S
AU  - Smith RS
LA  - eng
GR  - CA34196/CA/NCI NIH HHS/United States
GR  - EY11721/EY/NEI NIH HHS/United States
GR  - EYO7758/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Glaucoma
JT  - Journal of glaucoma
JID - 9300903
SB  - IM
MH  - Animals
MH  - Chromosome Mapping
MH  - *Disease Models, Animal
MH  - Glaucoma/*genetics/pathology
MH  - Humans
MH  - Intraocular Pressure/genetics
MH  - *Mice
RF  - 114
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
PST - ppublish
SO  - J Glaucoma. 1999 Dec;8(6):400-12.