PMID- 10603358
OWN - NLM
STAT- MEDLINE
DCOM- 20000216
LR  - 20220215
IS  - 0950-1991 (Print)
IS  - 0950-1991 (Linking)
VI  - 127
IP  - 2
DP  - 2000 Jan
TI  - Regulation of neurogenesis by interactions between HEN1 and neuronal LMO
      proteins.
PG  - 425-35
AB  - Basic-helix-loop-helix transcription factors regulate neurogenesis and neuronal
      differentiation by as yet unknown mechanisms. We show that an embryonic
      neuronal-specific basic-helix-loop-helix protein, HEN1 (also known as NSCL1 or
      NHLH), interacts with 'LIM only' proteins. Examination of the expression patterns
      of XHEN1 and XLMO-3, the Xenopus homologues of these human genes, reveals
      extensive overlap during early neurogenesis: at the onset of gastrulation on the 
      dorsal side of the blastopore lip and, subsequently, in the prospective neural
      plate. Binding of XLMO-3 increases the transcriptional activity of XHEN1 in vivo.
      Co-expression of these two genes in Xenopus embryos induces a cascade of
      expression of neuronal-specific basic-helix-loop-helix proteins that leads to
      neuronal differentiation. We propose that XHEN1, in concert with XLMO-3, is a
      critical regulator of neurogenesis.
FAU - Bao, J
AU  - Bao J
AD  - The Center for Neurobiology and Behavior, College of Physicians & Surgeons,
      Columbia University, New York, NY 10032, USA.
FAU - Talmage, D A
AU  - Talmage DA
FAU - Role, L W
AU  - Role LW
FAU - Gautier, J
AU  - Gautier J
LA  - eng
GR  - R01 NS029071/NS/NINDS NIH HHS/United States
GR  - NS29071/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - England
TA  - Development
JT  - Development (Cambridge, England)
JID - 8701744
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NEUROG1 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Transcription Factors)
RN  - 0 (Tubulin)
RN  - 148025-10-9 (NHLH1 protein, human)
RN  - 169238-82-8 (Neurogenic differentiation factor 1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cell Differentiation
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/*genetics/metabolism
MH  - Gene Expression Regulation, Developmental
MH  - Helix-Loop-Helix Motifs
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Molecular Sequence Data
MH  - Nerve Tissue Proteins/genetics/*metabolism
MH  - Neurons/*metabolism
MH  - Sequence Alignment
MH  - Transcription Factors/*metabolism
MH  - Tubulin/genetics
MH  - Xenopus/embryology
MH  - Yeasts/genetics
EDAT- 1999/12/22 09:00
MHDA- 2000/02/19 09:00
CRDT- 1999/12/22 09:00
PHST- 1999/12/22 09:00 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/12/22 09:00 [entrez]
AID - 10.1242/dev.127.2.425 [doi]
PST - ppublish
SO  - Development. 2000 Jan;127(2):425-35. doi: 10.1242/dev.127.2.425.