PMID- 10603087
OWN - NLM
STAT- MEDLINE
DCOM- 20000413
LR  - 20191103
IS  - 0949-944X (Print)
IS  - 0949-944X (Linking)
VI  - 210
IP  - 1
DP  - 2000 Jan
TI  - NKX2 gene expression in neuroectoderm but not in mesendodermally derived
      structures depends on sonic hedgehog in mouse embryos.
PG  - 47-50
AB  - NKX2 genes in vertebrates encode a sub- family of homeodomain-containing
      transcription factors which regulate morphogenetic events and cell
      differentiation during embryogenesis. In mouse embryos several NKX2 genes are
      expressed in the ventral midline domains of the neuroectoderm, while other NKX2
      genes are primarily expressed in the mesendoderm and mesendodermally derived
      organs, such as heart and gut. Within several patterning centers for tissue
      organization sonic hedgehog (Shh) is an important signal in the formation of
      ventral midline structures in vertebrate embryos. Here, we investigated the role 
      of Shh in the embryonic expression of six different but closely related NKX2
      genes in Shh null mutant mice. We found that expression of NKX2.1, NKX2.2, and
      NKX2.9 in neural domains requires Shh signaling, whereas NKX2.3, NKX2.5 and
      NKX2.6 expression in endoderm and mesoderm is independent of Shh.
FAU - Pabst, O
AU  - Pabst O
AD  - Department of Cell and Molecular Biology, Technical University of Braunschweig,
      Spielmannstrasse 7, D-38106 Braunschweig, Germany.
FAU - Herbrand, H
AU  - Herbrand H
FAU - Takuma, N
AU  - Takuma N
FAU - Arnold, H H
AU  - Arnold HH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Germany
TA  - Dev Genes Evol
JT  - Development genes and evolution
JID - 9613264
RN  - 0 (Hedgehog Proteins)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Proteins)
RN  - 0 (Trans-Activators)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Ectoderm
MH  - Embryonic Induction
MH  - Embryonic and Fetal Development/*genetics
MH  - *Gene Expression Regulation, Developmental
MH  - Hedgehog Proteins
MH  - Homeodomain Proteins/*genetics
MH  - Mesoderm
MH  - Mice
MH  - Proteins/*genetics
MH  - *Trans-Activators
MH  - Transcription Factors/*genetics
EDAT- 1999/12/22 09:00
MHDA- 2000/04/15 09:00
CRDT- 1999/12/22 09:00
PHST- 1999/12/22 09:00 [pubmed]
PHST- 2000/04/15 09:00 [medline]
PHST- 1999/12/22 09:00 [entrez]
AID - 02100047.427 [pii]
AID - 10.1007/pl00008188 [doi]
PST - ppublish
SO  - Dev Genes Evol. 2000 Jan;210(1):47-50. doi: 10.1007/pl00008188.