PMID- 10602995
OWN - NLM
STAT- MEDLINE
DCOM- 20000203
LR  - 20191210
IS  - 0938-8990 (Print)
IS  - 0938-8990 (Linking)
VI  - 11
IP  - 1
DP  - 2000 Jan
TI  - Genomic cloning, chromosomal mapping, and expression analysis of msal-2.
PG  - 64-8
AB  - Mutations of SALL1 related to spalt of Drosophila have been found to cause
      Townes-Brocks syndrome, suggesting a function of SALL1 for the development of
      anus, limbs, ears, and kidneys. No function is yet known for SALL2, another human
      spalt-like gene. The structure of SALL2 is different from SALL1 and all other
      vertebrate spalt-like genes described in mouse, Xenopus, and Medaka, suggesting
      that SALL2-like genes might also exist in other vertebrates. Consistent with this
      hypothesis, we isolated and characterized a SALL2 homologous mouse gene, Msal-2. 
      In contrast to other vertebrate spalt-like genes both SALL2 and Msal-2 encode
      only three double zinc finger domains, the most carboxyterminal of which only
      distantly resembles spalt-like zinc fingers. The evolutionary conservation of
      SALL2/Msal-2 suggests that two lines of sal-like genes with presumably different 
      functions arose from an early evolutionary duplication of a common ancestor gene.
      Msal-2 is expressed throughout embryonic development but also in adult tissues,
      predominantly in brain. However, the function of SALL2/Msal-2 still needs to be
      determined.
FAU - Kohlhase, J
AU  - Kohlhase J
AD  - Institut fur Humangenetik der Universitat Gottingen, Heinrich-Duker-Weg 12,
      D-37073 Gottingen, Germany. jkohla@gwdg.de
FAU - Altmann, M
AU  - Altmann M
FAU - Archangelo, L
AU  - Archangelo L
FAU - Dixkens, C
AU  - Dixkens C
FAU - Engel, W
AU  - Engel W
LA  - eng
SI  - GENBANK/AJ007396
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Mamm Genome
JT  - Mammalian genome : official journal of the International Mammalian Genome Society
JID - 9100916
RN  - 0 (Carrier Proteins)
RN  - 0 (DNA Primers)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Sall2 protein, mouse)
RN  - 63231-63-0 (RNA)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Carrier Proteins/chemistry/*genetics
MH  - *Chromosome Mapping
MH  - Cloning, Molecular
MH  - DNA/chemistry
MH  - DNA Primers/chemistry
MH  - DNA-Binding Proteins
MH  - *Gene Expression Regulation, Developmental
MH  - Gene Library
MH  - In Situ Hybridization, Fluorescence
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nucleic Acid Hybridization
MH  - RNA/chemistry/isolation & purification
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Sequence Alignment
MH  - Sequence Homology, Amino Acid
MH  - Zinc Fingers/*genetics
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - MG99-SB115 [pii]
AID - 10.1007/s003350010012 [doi]
PST - ppublish
SO  - Mamm Genome. 2000 Jan;11(1):64-8. doi: 10.1007/s003350010012.