PMID- 10602519
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20061115
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 52
DP  - 1999 Dec 9
TI  - Fusion of the RBP56 and CHN genes in extraskeletal myxoid chondrosarcomas with
      translocation t(9;17)(q22;q11).
PG  - 7594-8
AB  - Although most extraskeletal myxoid chondrosarcomas (EMC) are cytogenetically
      characterized by the translocation t(9;22)(q22;q12), another subset has recently 
      been identified carrying a t(9;17)(q22;q11). Whereas the t(9;22) is known to
      result in fusion of the CHN (TEC) gene from 9q22 with the EWS gene from 22q12,
      creating a chimeric EWS/CHN, the genes involved in the t(9;17) of EMC are
      unknown. We examined two EMC with t(9;17)(q22;q11) and found that the CHN gene
      was recombined with the RBP56 gene from 17q11 to generate a chimeric RBP56/CHN.
      RBP56 has not previously been shown to be involved in tumorigenesis but it
      encodes a putative RNA-binding protein similar to the EWS and FUS (TLS) proteins 
      known to play a pathogenetic role in several sarcomas. The presence of the
      RBP56/CHN chimeric gene in EMC with t(9;17)(q22;q11) shows that the N-terminal
      parts of EWS and RBP56 have similar oncogenic potential making them
      pathogenetically equivalent in oncoproteins arising from fusions with certain
      transcription factors.
FAU - Panagopoulos, I
AU  - Panagopoulos I
AD  - Department of Clinical Genetics, Lund University Hospital, S-221 85 Lund, Sweden.
FAU - Mencinger, M
AU  - Mencinger M
FAU - Dietrich, C U
AU  - Dietrich CU
FAU - Bjerkehagen, B
AU  - Bjerkehagen B
FAU - Saeter, G
AU  - Saeter G
FAU - Mertens, F
AU  - Mertens F
FAU - Mandahl, N
AU  - Mandahl N
FAU - Heim, S
AU  - Heim S
LA  - eng
SI  - GENBANK/AJ243810
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (NR4A3 protein, human)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Receptors, Steroid)
RN  - 0 (Receptors, Thyroid Hormone)
RN  - 0 (TAF15 protein, human)
RN  - 0 (TATA-Binding Protein Associated Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - *Artificial Gene Fusion
MH  - Base Sequence
MH  - Chondrosarcoma/*genetics
MH  - *Chromosomes, Human, Pair 17
MH  - Chromosomes, Human, Pair 9
MH  - DNA-Binding Proteins/*genetics
MH  - Humans
MH  - Molecular Sequence Data
MH  - *Nerve Tissue Proteins
MH  - Nuclear Proteins/*genetics
MH  - Receptors, Steroid
MH  - Receptors, Thyroid Hormone
MH  - *TATA-Binding Protein Associated Factors
MH  - Transcription Factors/*genetics
MH  - *Translocation, Genetic
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.onc.1203155 [doi]
PST - ppublish
SO  - Oncogene. 1999 Dec 9;18(52):7594-8. doi: 10.1038/sj.onc.1203155.