PMID- 10602503
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20200116
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 52
DP  - 1999 Dec 9
TI  - The cloning, mapping and expression of a novel gene, BRL, related to the AF10
      leukaemia gene.
PG  - 7442-52
AB  - The MLL gene is reciprocally translocated with one of a number of different
      partner genes in a proportion of human acute leukaemias. The precise mechanism of
      oncogenic transformation is unclear since most of the partner genes encode
      unrelated proteins. However, two partner genes, AF10 and AF17 are related through
      the presence of a cysteine rich region and a leucine zipper. The identification
      of other proteins with these structures will aid our understanding of their role 
      in normal and leukaemic cells. We report the cloning of a novel human gene (BRL) 
      which encodes a protein containing a cysteine rich region related to that of AF10
      and AF17 and is overall most closely related to the previously known protein
      BR140. BRL maps to chromosome 22q13 and shows high levels of expression in testis
      and several cell lines. The deduced protein sequence also contains a bromodomain,
      four potential LXXLL motifs and four predicted nuclear localization signals. A
      monoclonal antibody raised to a BRL peptide sequence confirmed its widespread
      expression as a 120 Kd protein and demonstrated localization to the nucleus
      within spermatocytes.
FAU - McCullagh, P
AU  - McCullagh P
AD  - Imperial Cancer Research Fund, Department of Medical Oncology, St Bartholomew's
      and the Royal London School of Medicine and Dentistry, Charterhouse Square,
      London ECIM 6BQ, UK.
FAU - Chaplin, T
AU  - Chaplin T
FAU - Meerabux, J
AU  - Meerabux J
FAU - Grenzelias, D
AU  - Grenzelias D
FAU - Lillington, D
AU  - Lillington D
FAU - Poulsom, R
AU  - Poulsom R
FAU - Gregorini, A
AU  - Gregorini A
FAU - Saha, V
AU  - Saha V
FAU - Young, B D
AU  - Young BD
LA  - eng
SI  - GENBANK/AF005067
SI  - GENBANK/Z98885
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Histone Chaperones)
RN  - 0 (MLLT10 protein, human)
RN  - 0 (MLLT6 protein, human)
RN  - 0 (Mllt10 protein, mouse)
RN  - 0 (Mllt6 protein, mouse)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - EC 2.3.1.48 (BRD1 protein, human)
SB  - IM
MH  - Amino Acid Motifs
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Chromosome Mapping
MH  - Cloning, Molecular
MH  - *DNA-Binding Proteins
MH  - Expressed Sequence Tags
MH  - Gene Expression Profiling
MH  - Histone Chaperones
MH  - Humans
MH  - In Situ Hybridization/methods
MH  - Leukemia/genetics
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics
MH  - Nuclear Proteins/*genetics/*metabolism
MH  - Sequence Analysis
MH  - Subcellular Fractions
MH  - Testis/metabolism
MH  - Transcription Factors/*genetics
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.onc.1203117 [doi]
PST - ppublish
SO  - Oncogene. 1999 Dec 9;18(52):7442-52. doi: 10.1038/sj.onc.1203117.