PMID- 10602502
OWN - NLM
STAT- MEDLINE
DCOM- 20000113
LR  - 20191210
IS  - 0950-9232 (Print)
IS  - 0950-9232 (Linking)
VI  - 18
IP  - 52
DP  - 1999 Dec 9
TI  - Tob2, a novel anti-proliferative Tob/BTG1 family member, associates with a
      component of the CCR4 transcriptional regulatory complex capable of binding
      cyclin-dependent kinases.
PG  - 7432-41
AB  - Human cDNAs encoding a novel member of Tob/BTG1 anti-proliferative family
      proteins were cloned. The putative protein product termed Tob2 consisted of 344
      amino acids with high similarity to the Tob protein. The tob2 mRNA was 4.1 kb
      long and was ubiquitously expressed in human adult tissues, as was revealed by
      Northern blot hybridization. However, further in situ hybridization analysis
      showed a characteristic expression of the tob2 mRNA in oocytes, suggesting a
      unique role of Tob2 in oogenesis. Like the Tob protein, Tob2 inhibited cell cycle
      progression from the G0/G1 to S phases. Intriguingly, the amino-terminal half of 
      Tob2 as well as that of Tob was associated with a human homologue of yeast Caf1, 
      a component of the CCR4 transcription factor complex. Moreover, Caf1 was
      associated with cyclin dependent kinases. These data suggested that both Tob and 
      Tob2 were involved in cell cycle regulation through their interaction with Caf1. 
      Finally, the tob2 gene was mapped to human chromosome 22q13.1-q13.31.
FAU - Ikematsu, N
AU  - Ikematsu N
AD  - Department of Oncology, The Institute of Medical Science, The University of
      Tokyo, Minato-ku, Tokyo 108-8639, Japan.
FAU - Yoshida, Y
AU  - Yoshida Y
FAU - Kawamura-Tsuzuku, J
AU  - Kawamura-Tsuzuku J
FAU - Ohsugi, M
AU  - Ohsugi M
FAU - Onda, M
AU  - Onda M
FAU - Hirai, M
AU  - Hirai M
FAU - Fujimoto, J
AU  - Fujimoto J
FAU - Yamamoto, T
AU  - Yamamoto T
LA  - eng
SI  - GENBANK/D64109
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Oncogene
JT  - Oncogene
JID - 8711562
RN  - 0 (Btg1 protein, mouse)
RN  - 0 (CNOT8 protein, human)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cell Cycle Proteins)
RN  - 0 (Intracellular Signaling Peptides and Proteins)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proteins)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (TOB1 protein, human)
RN  - 0 (TOB2 protein, human)
RN  - 0 (Tob1 protein, mouse)
RN  - 0 (Tob2 protein, mouse)
RN  - 0 (Transcription Factors)
RN  - 0 (Tumor Suppressor Proteins)
RN  - 146835-72-5 (BTG1 protein, human)
RN  - EC 2.7.11.1 (Protein-Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDC2-CDC28 Kinases)
RN  - EC 2.7.11.22 (CDK2 protein, human)
RN  - EC 2.7.11.22 (CDK4 protein, human)
RN  - EC 2.7.11.22 (Cdk2 protein, mouse)
RN  - EC 2.7.11.22 (Cdk4 protein, mouse)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 2)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinase 4)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
RN  - EC 3.1.- (Cnot7 protein, mouse)
RN  - EC 3.1.- (Ribonucleases)
SB  - IM
MH  - 3T3 Cells/cytology/metabolism
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - *CDC2-CDC28 Kinases
MH  - Carrier Proteins/metabolism
MH  - Cell Cycle Proteins/*genetics/*metabolism
MH  - Cell Line
MH  - Cloning, Molecular
MH  - Cyclin-Dependent Kinase 2
MH  - Cyclin-Dependent Kinase 4
MH  - Cyclin-Dependent Kinases/*metabolism
MH  - G1 Phase/genetics
MH  - Gene Expression Profiling
MH  - Humans
MH  - *Intracellular Signaling Peptides and Proteins
MH  - Male
MH  - Mice
MH  - Molecular Sequence Data
MH  - Neoplasm Proteins/genetics
MH  - Protein-Serine-Threonine Kinases/metabolism
MH  - *Proteins
MH  - *Proto-Oncogene Proteins
MH  - Rabbits
MH  - Ribonucleases
MH  - Sequence Homology, Amino Acid
MH  - Subcellular Fractions
MH  - Transcription Factors/genetics/*metabolism
MH  - *Tumor Suppressor Proteins
EDAT- 1999/12/22 00:00
MHDA- 1999/12/22 00:01
CRDT- 1999/12/22 00:00
PHST- 1999/12/22 00:00 [pubmed]
PHST- 1999/12/22 00:01 [medline]
PHST- 1999/12/22 00:00 [entrez]
AID - 10.1038/sj.onc.1203193 [doi]
PST - ppublish
SO  - Oncogene. 1999 Dec 9;18(52):7432-41. doi: 10.1038/sj.onc.1203193.